研究成果の概要（英文）：We aim to demonstrate the evolutionary importance of fragile sites. Fragile
sites are hot spots of mutation, which are usually selected against. In this sense, they are
evolutionary useless. Here, we hypothesized that a genome has some benefit if it has fragile sites,
especially when the host species face environmental changes and has to adapt in a short time. To
demonstrate this, we investigated genomes of various species. For example, we found a number of
genes have been integrated in the genome of parasite plants, and there seem to be hotspots of
integration, where multiple genes are integrated (Kado Inann 2018 Genome Biol. Evol.). We also
investigated the genome of domesticated horse, from which we found a number of regions that have
changed dramatically in the domestication process.
ゲノムの脆弱部位を利用した適応進化
運用要項