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oai:ir.soken.ac.jp:00004039 2023-06-20T14:27:40Z 1:276 1:285 1:314

Genomic structure and evolution of multigene families: “Flowers” on the human genome Genomic structure and evolution of multigene families: “Flowers” on the human genome 尚之, 高畑 KIM, Hie Lim IWASE, Mineyo IGAWA, Takeshi NISHIOKA, Tasuku KANEKO, Satoko KATSURA, Yukako TAKAHATA, Naoyuki SATTA, Yoko © 2012 Hie Lim Kim et al. application/pdf We report the results of an extensive investigation of genomic structures in the human genome, with a particular focus on relatively large repeats (>50 kb) in adjacent chromosomal regions. We named such structures “Flowers” because the pattern observed on dot plots resembles a flower. We detected a total of 291 Flowers in the human genome. They were predominantly located in euchromatic regions. Flowers are gene-rich compared to the average gene density of the genome. Genes involved in systems receiving environmental information, such as immunity and detoxification, were overrepresented in Flowers. Within a Flower, the mean number of duplication units was approximately four. The maximum and minimum identities between homologs in a Flower showed different distributions; the maximum identity was often concentrated to 100% identity, while the minimum identity was evenly distributed in the range of 78% to 100%. Using a gene conversion detection test, we found frequent and/or recent gene conversion events within the tested Flowers. Interestingly, many of those converted regions contained protein-coding genes. Computer simulation studies suggest that one role of such frequent gene conversions is the elongation of the life span of gene families in a Flower by the resurrection of pseudogenes. Hindawi Publishing Corporation 2012 eng journal article VoR https://ir.soken.ac.jp/records/4039 http://dx.doi.org/10.1155/2012/917678 10.1155/2012/917678 http://www.hindawi.com/journals/apm/apc/ Copyright 2090-052X International Journal of Evolutionary Biology International Journal of Evolutionary Biology Article ID 917678 11 https://ir.soken.ac.jp/record/4039/files/917678[1].pdf application/pdf 1.8 MB 2013-10-25