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oai:ir.soken.ac.jp:00003703 2023-06-20T14:31:11Z 1:285 1:314

Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates 尚之, 高畑 SAWAI, Hiromi KAWAMOTO, Yoshi TAKAHATA, Naoyuki SATTA, Yoko New World monkeys (NWMs) occupy a critical phylogenetic position in elucidating the evolutionary process of major histocompatibility complex (MHC) class I genes in primates. From three subfamilies of Aotinae, Cebinae, and Atelinae, the 5′-flanking regions of 18 class I genes are obtained and phylogenetically examined in terms of Alu/LINE insertion elements as well as the nucleotide substitutions. Two pairs of genes from Aotinae and Atelinae are clearly orthologous to human leukocyte antigen (HLA) -E and -F genes. Of the remaining 14 genes, 8 belong to the distinct group B, together with HLA-B and -C, to the exclusion of all other HLA class I genes. These NWM genes are classified into four groups, designated as NWM-B1, -B2, -B3, and -B4. Of these, NWM-B2 is orthologous to HLA-B/C. Also, orthologous relationships of NWM-B1, -B2, and -B3 exist among different families of Cebidae and Atelidae, which is in sharp contrast to the genus-specific gene organization within the subfamily Callitrichinae. The other six genes belong to the distinct group G. However, a clade of these NWM genes is almost equally related to HLA-A, -J, -G, and -K, and there is no evidence for their orthologous relationships to HLA-G. It is argued that class I genes in simian primates duplicated extensively in their common ancestral lineage and that subsequent evolution in descendant species has been facilitated mainly by independent loss of genes. journal article The Genetics Society of America 2004-04 Genetics 4 166 1897 1907 Genetics 00166731 https://ir.soken.ac.jp/records/3703 eng 15126407 10.1534/genetics.166.4.1897 https://doi.org/10.1534/genetics.166.4.1897 © 2004 by The Genetics Society of America metadata only access