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The Extent of Linkage Disequilibrium and Haplotype Sharing Around a Polymorphic Site
The Extent of Linkage Disequilibrium and Haplotype Sharing Around a Polymorphic Site
印南, 秀樹
INNAN, Hideki
NORDBORG, Magnus
Various expressions related to the length of a conserved haplotype around a polymorphism of known frequency are derived. We obtain exact expressions for the probability that no recombination has occurred in a sample or subsample. We obtain an approximation for the probability that no recombination that could give rise to a detectable recombination event (through the four-gamete test) has occurred. The probabilities can be used to obtain approximate distributions for the length of variously defined haplotypes around a polymorphic site. The implications of our results for data analysis, and in particular for detecting selection, are discussed.
journal article
The Genetics Society of America
2003-09-01
Genetics
1
165
437
444
Genetics
0016-6731
eng
The Genetics Society of America
http://www.genetics.org/content/genetics/165/1/437.full.pdf
© 2003 by The Genetics Society of America
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