{"created":"2023-06-20T13:21:02.483311+00:00","id":1135,"links":{},"metadata":{"_buckets":{"deposit":"16d622b5-2fbc-44d9-9cce-5385e08013b6"},"_deposit":{"created_by":1,"id":"1135","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"1135"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00001135","sets":["2:430:22"]},"author_link":["9420","9422","9421"],"item_1_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"常川, 直子"}],"nameIdentifiers":[{}]}]},"item_1_creator_3":{"attribute_name":"フリガナ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ツナカワ, ナオコ"}],"nameIdentifiers":[{}]}]},"item_1_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2003-03-24"}]},"item_1_degree_grantor_5":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"総合研究大学院大学"}]}]},"item_1_degree_name_6":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（理学）"}]},"item_1_description_12":{"attribute_name":"要旨","attribute_value_mlt":[{"subitem_description":"  γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS).  The levels of GABA and its synthetic enzyme glutamate decarboxylase (GAD) in superior colliculus (SC) are high.  They investigated the early development of SC, including early GABAergic neurons, using GAD67-GFP knock-in (GAD67+-/- and GFP+/-) mice to mark GABAergic neurons and observe their migration.<br />  It was revealed by observation of cells labeled with BrdU that neurons in mouse SC generated from E 11.5 to E 15.5 with a peak at E 13.5.  The generation of GABAergic neurons had a peak at E 12.5 and they migrated and spread throughout SC by E 16.5.  By BrdU and DsRed2 labeling, the inside-out cell migration pattern was not evident in SC compared with that in neocortex.  They observed the shape of cell bodies, arrangements, nestin-immunoreactivity of SC cells, and time-lapse of living GABAergic neurons.  These observations indicated radial migration of GABAergic neurons and generation in the ventricular zone.  They made cuts at an early stage that intercept either or both radial and tangential cell migration in SC, and the result of this experiment also supported our conclusion.  It was also noticeable that the surface of the SC was covered with GABAergic fibers at an early stage, when GABAergic cells were not yet differentiated in SC.","subitem_description_type":"Other"}]},"item_1_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_1_description_7":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"総研大甲第704号","subitem_description_type":"Other"}]},"item_1_select_14":{"attribute_name":"所蔵","attribute_value_mlt":[{"subitem_select_item":"有"}]},"item_1_select_8":{"attribute_name":"研究科","attribute_value_mlt":[{"subitem_select_item":"生命科学研究科"}]},"item_1_select_9":{"attribute_name":"専攻","attribute_value_mlt":[{"subitem_select_item":"20 生理科学専攻"}]},"item_1_text_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"2002"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TSUNAKAWA, Naoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"simple","filename":"甲704_要旨.pdf","filesize":[{"value":"184.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"要旨・審査要旨 / Abstract, Screening Result","url":"https://ir.soken.ac.jp/record/1135/files/甲704_要旨.pdf"},"version_id":"bd3e5852-0b69-41f9-94b6-324a78c2e9b2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"simple","filename":"甲704_本文.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","url":"https://ir.soken.ac.jp/record/1135/files/甲704_本文.pdf"},"version_id":"9fa4286b-a21a-4479-98a6-014bc592b436"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Development of GABAergic neurons in mouse superior colliculus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of GABAergic neurons in mouse superior colliculus"},{"subitem_title":"Development of GABAergic neurons in mouse superior colliculus","subitem_title_language":"en"}]},"item_type_id":"1","owner":"1","path":["22"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-02-22"},"publish_date":"2010-02-22","publish_status":"0","recid":"1135","relation_version_is_last":true,"title":["Development of GABAergic neurons in mouse superior colliculus"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-06-20T14:47:13.118359+00:00"}