@misc{oai:ir.soken.ac.jp:00001179,
 author = {中田, 大貴 and ナカタ, ヒロキ and NAKATA, Hiroki},
 month = {2016-02-17, 2016-02-17},
 note = {The go/nogo task is a useful paradigm for recording event-related<br />potentials (ERPs) to investigate the neural mechanisms of response<br />inhibition.  In nogo trials, a negative deflection at around 140-300 ms,<br />which has been called the ‘nogo potentials’ is elicited at the frontocentral <br />electrodes, compared with ERPs recorded in go trials.  In the first study, <br />we investigated the generators for nogo potentials by recording <br />magnetoencephalography (MEG) during somatosensory go/nogo tasks.  <br />MEG data revealed that a long-latency response peaking at approximately <br />160 ms, termed nogo-M170, recorded in only nogo trials.  The equivalent <br />current dipole (ECD) of nogo-M170 was estimated to lie around the <br />posterior part of the inferior frontal sulci in the prefrontal cortex.  This <br />finding clarified the spatial and temporal processing related to <br />somato-motor inhibition caused in the posterior part of the inferior frontal <br />sulci in the prefrontal cortex in humans.<br />In the second study, we investigated the effect of the inhibitory <br />processing with increasing muscle force on motor evoked potentials <br />(MEPs) elicited by transcranial magnetic stimulation (TMS).  The <br />subjects performed a warning stimulus (S1) －imperative stimulus (S2) <br />paradigm with go/nogo tasks.  S1 was an auditory tone burst, and S2 was <br />an electrical stimulation for the second (go stimuli) or fifth digit (nogo <br />stimuli) of the left hand at an even probability in go/nogo tasks.  The <br />recordings were conducted at three force levels; 10 %, 30 % and 50 % <br />maximal voluntary contraction (MVC).  After the presentation of S2, the <br />subjects were asked to adjust their force level so as to match the target line <br />with a force trajectory line as quickly and accurately as possible in only the <br />go trials.  The amplitude of the MEP, which was recorded from the first <br />dorsal interosseous (FDI) muscle 150 ms after S2, in nogo trials became <br />significantly smaller with increasing muscle force, whereas it became <br />larger in go trials.  Our results indicated that stronger inhibitory cerebral <br />activity was needed for a nogo stimulus, in the case where a stronger <br />response was needed for a go stimulus., application/pdf, 総研大甲第1008号},
 title = {Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm},
 year = {}
}