{"created":"2023-06-20T13:21:53.386376+00:00","id":2191,"links":{},"metadata":{"_buckets":{"deposit":"868bbb3b-7104-4967-9db9-a353cde48adf"},"_deposit":{"created_by":21,"id":"2191","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"2191"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00002191","sets":["33:34"]},"author_link":["345","346"],"item_2_creator_3":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"WATANABE, Masakatsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_2_date_4":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-06-10","subitem_date_issued_type":"Created"}]},"item_2_description_13":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"18077003","subitem_description_type":"Other"}]},"item_2_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"研究期間","attribute_value_mlt":[{"subitem_description":"2006～2010","subitem_description_type":"Other"}]},"item_2_description_17":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々がミドリムシから発見した、光を感じて細胞諸機能制御因子環状AMPを生成する光活性化アデニル酸シクラーゼ(PAC)について:4量体構造をとり、水素結合ネットワークの異なる2状態を行き来し、高感度・低速度とその逆の2成分から成ることを解明;光感受に伴う蛋白質構造変化の解析に強力な一分子赤外線吸収分光法を開発;複数の生物に遺伝子的に導入して神経活動や行動の光制御に成功;その遺伝子の染色体上局在を多数検出。\r\n\r\nBiophysical studies performed to elucidate the mechanisms how the euglenoid pbotoreceptor photoactivated adenylyl cyclase (PAC) converts light signal to cyclic AMP, the versatile second messenger, have led to the following outcomes: electron micrographic details of its tetrameric structure, spectroscopic unveiling of its two states of hydrogen bond networks, division of labor between high-sensitivity-low-speed and the opposite subunits, invention of the single-protein infrared spectroscopic method, photomanipulation of neuronal and behavioral activities of various organisms by heterologous expression of PAC, and elucidation of PAC gene localization along the <i>Euglena</i>chromosomes.","subitem_description_type":"Abstract"}]},"item_2_description_18":{"attribute_name":"科研費研究者番号","attribute_value_mlt":[{"subitem_description":"40124226 | http://rns.nii.ac.jp/nr/1000040124226","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"科学研究費補助金研究成果報告書\r\n研究代表者：渡辺正勝 ［総合研究大学院大学 先導科学研究科教授］\r\n研究分担者：伊関峰生 ［総合研究大学院大学　学融合推進センター特別研究員］\r\n小川和男 ［自然科学研究機構　岡崎共通研究アイソトープ実験センター准教授］","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN（科学研究費補助金データベース）"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://kaken.nii.ac.jp/ja/r/40124226","subitem_relation_type_select":"URI"}}]},"item_2_text_19":{"attribute_name":"研究分野","attribute_value_mlt":[{"subitem_text_value":"生物学"}]},"item_2_text_20":{"attribute_name":"研究種目","attribute_value_mlt":[{"subitem_text_value":"特定領域研究"}]},"item_2_text_21":{"attribute_name":"科研費の分科・細目","attribute_value_mlt":[{"subitem_text_value":"基礎生物学・植物分子生物・生理学 / 生物科学・機能生物化学"}]},"item_2_text_5":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_text_value":"2010"}]},"item_2_version_type_12":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 正勝"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-02-05"}],"displaytype":"simple","filename":"18077003seika.pdf","filesize":[{"value":"266.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"研究成果報告書","url":"https://ir.soken.ac.jp/record/2191/files/18077003seika.pdf"},"version_id":"6e5ac206-3d33-499c-8093-7eb70d0d545c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"光センサー","subitem_subject_scheme":"Other"},{"subitem_subject":"フラビン","subitem_subject_scheme":"Other"},{"subitem_subject":"環状AMP","subitem_subject_scheme":"Other"},{"subitem_subject":"ドメイン相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞行動","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"一人三役の光センサー蛋白、光活性化アデニル酸シクラーゼの分子内ドメイン相互作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"一人三役の光センサー蛋白、光活性化アデニル酸シクラーゼの分子内ドメイン相互作用"},{"subitem_title":"Interactions among intramolecular domains of Photoactivated Adenylyl Cyclase (PAC), the blue-light sensor with intrinsic effector function","subitem_title_language":"en"}]},"item_type_id":"2","owner":"21","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-15"},"publish_date":"2011-07-15","publish_status":"0","recid":"2191","relation_version_is_last":true,"title":["一人三役の光センサー蛋白、光活性化アデニル酸シクラーゼの分子内ドメイン相互作用"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-06-20T15:29:46.804213+00:00"}