{"created":"2023-06-20T13:22:33.329760+00:00","id":3210,"links":{},"metadata":{"_buckets":{"deposit":"c54c8bc6-73ac-4944-a4d0-d5eb284452f6"},"_deposit":{"created_by":21,"id":"3210","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3210"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003210","sets":["33:34"]},"author_link":["357","356"],"item_2_creator_3":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATTA, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_2_date_4":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-06-04","subitem_date_issued_type":"Created"}]},"item_2_description_13":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"２１３７０１０６","subitem_description_type":"Other"}]},"item_2_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"研究期間","attribute_value_mlt":[{"subitem_description":"2009～2011","subitem_description_type":"Other"}]},"item_2_description_17":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：チトクロームP450（CYP）は生体内外に由来する物質の代謝に関わ\r\nる酵素である。この酵素の種類は生物によって異なることが知られており、生息環境や食性の\r\n違いを反映していると考えられる。本研究では、特に、薬物の代謝に関わるCYP サブファミ\r\nリーの分子進化や肝臓での発現解析を行い、CYP の多様化の生物学的機構を明らかにすること\r\nを目的とした。その結果、サブファミリーの起源は、羊膜類と両生類との共通祖先にまで遡る\r\nこと、またその酵素の基質特異性を決める領域での特異的な進化の様相を明らかにした。\r\n研究成果の概要（英文）：CytochromoeP450 (CYP) is an enzyme that is involved in\r\nmetabolism of chemicals derived from inside or outside of bodies. The variety of the\r\nenzymes is observed among different species, probably reflecting the difference in habitats\r\nor diets of species. To know biological mechanism for diversifying enzymes among species,\r\nwe examined molecular evolution of CYP2D subfamily that is involved in drag metabolism、\r\nand CYP mRNA expression differences between primate species. The analysis shows the\r\norigin of the subfamily in an ancestor of amphibian and Amniota and the specific feature of\r\nevolution at amino acid substitutions at the substrate recognition sites of the enzyme.","subitem_description_type":"Abstract"}]},"item_2_description_18":{"attribute_name":"科研費研究者番号","attribute_value_mlt":[{"subitem_description":"20222010 | http://rns.nii.ac.jp/d/nr/1000020222010","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"科学研究費補助金研究成果報告書 \r\n研究代表者：颯田葉子［総合研究大学院大学先導科学研究科教授］\r\n連携研究者：西岡輔［総合研究大学院大学先導科学研究科先導研特別研究員］\r\n安河内彦輝［総合研究大学院大学先導科学研究科先導研特別研究員］\r\n研究協力者：川嶋彩夏［総合研究大学院大学先導科学研究科５年一貫性博士課程学生］","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN（科学研究費補助金データーベース） "}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://kaken.nii.ac.jp/d/r/20222010.ja.html","subitem_relation_type_select":"URI"}}]},"item_2_text_19":{"attribute_name":"研究分野","attribute_value_mlt":[{"subitem_text_value":"生物学"}]},"item_2_text_20":{"attribute_name":"研究種目","attribute_value_mlt":[{"subitem_text_value":"基盤研究（B）"}]},"item_2_text_21":{"attribute_name":"科研費の分科・細目","attribute_value_mlt":[{"subitem_text_value":"生物科学、進化生物学"}]},"item_2_text_5":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_text_value":"2012"}]},"item_2_version_type_12":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"颯田, 葉子"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-01-01"}],"displaytype":"simple","filename":"21370106seika.pdf","filesize":[{"value":"416.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"研究成果報告書","url":"https://ir.soken.ac.jp/record/3210/files/21370106seika.pdf"},"version_id":"694e2571-6a40-4bc4-a722-0efadc740e97"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"環境、遺伝的多型、基質特異性、霊長類、、偽遺伝子化、人類進化、遺伝子重複","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"霊長類チトクロームP４５０遺伝子群の多型・発現・バースアンドデス","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"霊長類チトクロームP４５０遺伝子群の多型・発現・バースアンドデス"},{"subitem_title":"Polymorphism,gene expression and birth and death processe of primate cytochrome  P450 gene family","subitem_title_language":"en"}]},"item_type_id":"2","owner":"21","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-01"},"publish_date":"2012-01-01","publish_status":"0","recid":"3210","relation_version_is_last":true,"title":["霊長類チトクロームP４５０遺伝子群の多型・発現・バースアンドデス"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-06-20T15:29:53.079912+00:00"}