{"created":"2023-06-20T13:22:35.020190+00:00","id":3242,"links":{},"metadata":{"_buckets":{"deposit":"5797a3ba-63a3-4e1d-aa5b-1e666eaf01ed"},"_deposit":{"created_by":21,"id":"3242","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3242"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003242","sets":["33:34"]},"author_link":["410","411"],"item_2_creator_3":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OTA, Tatsuya ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"411","nameIdentifierScheme":"WEKO"}]}]},"item_2_date_4":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-06","subitem_date_issued_type":"Created"}]},"item_2_description_13":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"16570187","subitem_description_type":"Other"}]},"item_2_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"研究期間","attribute_value_mlt":[{"subitem_description":"2004年度～2006年度","subitem_description_type":"Other"}]},"item_2_description_17":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"スズキ類ノトセニア亜目の魚類が極限環境で生息できるのはAFGPを進化の過程で獲得したことが一つの要因である。今回、塩基配列の解析でAFGP遺伝子の起源はノトセニア科、ハルパギファ科、アゴヒゲオコゼ科、カモグチウオ科、コオリウオ科が分化し始める頃の2180〜2430万年前と推定された。\r\n\r\nNearら(2006)はノトセニア亜目コオリウオ科の15種で成魚型のヘモグロビン遺伝子がゲノムからほぼ失われているのに対し1種でα遺伝子が残っていることを発見しコオリウオ科の種分化の過程で多型対立遺伝子が維持されたと結論した。偽遺伝子であるこれら二つのハプロタイプが数百万年にわたる種分化の間で中立的に維持され続けるには非常に大きな集団が遺伝的に必要となる。現在のミトコンドリアの配列解析からはいくつかの種で十万から百万の桁の有効な集団の大きさが推定されるが、現在の集団は比較的最近拡張したものであること、数百万年もの間対立遺伝子を中立的に存続するために必要な有効な集団の大きさは現在でも上限に近いこと、さらにその間に生物の種分化が数度起きていることを考えると観察されたハプロタイプが中立的に多型対立遺伝子として長期存在した可能性は低いと考えられる。ヘモグロビンの塩基配列解析からコオリウオ科の系統で正の自然選択が見出されたことから、これらの多型対立遺伝子の維持にも自然選択がかかったことも考えられる。\r\n\r\nミトコンドリア遺伝子での研究からライギョダマシは遺伝的に均一であることが示されたが、主要組織適合遺伝子複合体においては多型が観察され過去により大きな集団を構成していたことが類推された。また免疫グロブリン遺伝子の解析ではオリゴヌクレオチドの重複がAFGPと同様に重要な役割を果たしていることが示された。\r\n\r\nIn this project, the origin of antifreeze glycopeptides of notothenioid fishes was estimated to be about 21.8-24.3 million years ago, which corresponded to the time when fishes of notothens, plunderfishes, dragonfishes, and icefishes, were about to be diverged.\r\n\r\nNear et al. (2006) have recently identified that one species of icefish has retained alpha globin gene but not other 15 species of icefishes and have suspected that at least the two haplotypes had coexisted for the period of successive icefish speciations. A large effective population size is expected for two pseudogene haplotypes to be maintained neutrally for millions of years but various estimates of effective population size inferred for several existing species from mtDNA polymorphism (several hundred thousands to millions) are barely the minimum effective size of population to account for the situation. Considering that the most species studied have likely been subject to recent population expansion and that apparent positive selection is detected for the icefish alpha hemoglobin gene, some type of selection is speculated to maintain allelic pseudogenes for prolonged period in the past.\r\n\r\nDespite of limited nucleotide diversity of mitochondrial gene observed for Antarctic toothfish Dissostichus mawsoni, nucleotide sequence variation among individuals is detected at major histocompatibility complex gene class II beta genes, indicating larger population size of the species in the past. For the immunoglobulin gene, nucleotide duplication has caused rapid change of protein structure as in the case of antifreeze glycopeptides and it raised possibility that gene and nucleotide duplications have played significant roles in the evolution of notothenioid genome.","subitem_description_type":"Abstract"}]},"item_2_description_18":{"attribute_name":"科研費研究者番号","attribute_value_mlt":[{"subitem_description":"30322100 | http://rns.nii.ac.jp/d/nr/1000030322100","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"科学研究費補助金研究成果報告書 \r\n研究代表者：大田竜也 ［総合研究大学院大学先導科学研究科助教授］","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN（科学研究費補助金データーベース）"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://rns.nii.ac.jp/d/nr/1000030322100","subitem_relation_type_select":"URI"}}]},"item_2_text_19":{"attribute_name":"研究分野","attribute_value_mlt":[{"subitem_text_value":"進化生物学"}]},"item_2_text_20":{"attribute_name":"研究種目","attribute_value_mlt":[{"subitem_text_value":"基盤研究(C)"}]},"item_2_text_21":{"attribute_name":"科研費の分科・細目","attribute_value_mlt":[{"subitem_text_value":"進化生物学"}]},"item_2_text_5":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_text_value":"2004年度～2006年度"}]},"item_2_version_type_12":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大田, 竜也 "}],"nameIdentifiers":[{"nameIdentifier":"410","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-04-03"}],"displaytype":"simple","filename":"16570187seika.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"研究成果報告書","url":"https://ir.soken.ac.jp/record/3242/files/16570187seika.pdf"},"version_id":"40c00f85-eeb1-441f-95a9-b66a3b6f9e71"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"スズキ類ノトセニア亜目魚類における集団動態-適応進化と中立進化の検証-","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"スズキ類ノトセニア亜目魚類における集団動態-適応進化と中立進化の検証-"},{"subitem_title":"Population dynamics of notothenioid fishes. - Examination of adaptive evolution and neutral evolution -","subitem_title_language":"en"}]},"item_type_id":"2","owner":"21","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-20"},"publish_date":"2012-11-20","publish_status":"0","recid":"3242","relation_version_is_last":true,"title":["スズキ類ノトセニア亜目魚類における集団動態-適応進化と中立進化の検証-"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-06-20T15:30:08.132769+00:00"}