{"created":"2023-06-20T13:22:35.190229+00:00","id":3246,"links":{},"metadata":{"_buckets":{"deposit":"fa515697-c1d4-4685-a1b8-526aaa33315b"},"_deposit":{"created_by":21,"id":"3246","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3246"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003246","sets":["33:208:265"]},"author_link":["415","354","418"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_8_creator_4":{"attribute_name":"フリガナ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ササキ, アキラ"}],"nameIdentifiers":[{}]}]},"item_8_description_10":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題名：物理を基礎とする生命科学","subitem_description_type":"Other"}]},"item_8_description_21":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"インフノレエンザウィノレス, AIDS ウィノレス,トリパノソーマなど急速に進化す\r\nる病原体は,ワクチンや薬剤に対する抵抗性を急速に進化させ,また宿主免疫\r\nの攻撃目標となるエピトープを変えることによって,ワクチン接種や自然免疫\r\nからエスケープする.表面抗原の特定の領域のアミノ酸配列で定義されるエピ\r\nトープは,宿主免疫系との強い相互作用による頻度依存淘汰を受け,多次元配\r\n列空間のなかを「予測不可能な」軌跡を描いて進化し,また系統樹上の新しい\r\n枝が分岐し,多様化する.このような病原体の表現型(抗原型)と配列の進化\r\nを取り扱うための数学的理論はまだ確立されておらず,有効な流行予測や防除\r\n政策立案を阻むおおきな問題点となっている.本研究課題では,申請者が開発\r\nしてきた宿主と病原体の共進化理論や,病原体の配列進化・系統樹分岐理論を\r\n発展させ,宿主の集団免疫構造と病原体エピトープの共進化を数理モデル化し,\r\n流行と進化の予測を可能にする理論の構築を試みた.","subitem_description_type":"Abstract"}]},"item_8_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"葉山高等研究所センター"}]},"item_8_version_type_22":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 顕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAKI, Akira ","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-11-27"}],"displaytype":"detail","filename":"sasaki.pdf","filesize":[{"value":"879.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"sasaki","url":"https://ir.soken.ac.jp/record/3246/files/sasaki.pdf"},"version_id":"63ca7966-6300-4c79-9531-e05546fbbf96"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"病原体の進化予卸上表現型とエピトープ配列の進化動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"病原体の進化予卸上表現型とエピトープ配列の進化動態"}]},"item_type_id":"8","owner":"21","path":["265"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-26"},"publish_date":"2012-11-26","publish_status":"0","recid":"3246","relation_version_is_last":true,"title":["病原体の進化予卸上表現型とエピトープ配列の進化動態"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-06-20T15:36:42.294951+00:00"}