{"created":"2023-06-20T13:22:37.742840+00:00","id":3289,"links":{},"metadata":{"_buckets":{"deposit":"8036b6d8-7a1c-43e7-913d-0142386500c1"},"_deposit":{"created_by":21,"id":"3289","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3289"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003289","sets":["1:273"]},"author_link":["733","732","730","373","374","727","729","720","723","731","728","722"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"3513","bibliographicPageStart":"3505","bibliographicVolumeNumber":"144","bibliographic_titles":[{"bibliographic_title":"Endocrinology "},{"bibliographic_title":"Endocrinology ","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"飯田, 香穂里"}],"nameIdentifiers":[{},{},{}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Humans afflicted with the Wolcott-Rallison syndrome and mice deficient for PERK (pancreatic endoplasmic reticulum eIF2α kinase) show severe postnatal growth retardation. In mice, growth retardation in Perk−/− mutants is manifested within the first few days of neonatal development. Growth parameters of Perk−/− mice, including comparison of body weight to length and organ weights, are consistent with proportional dwarfism. Tibia growth plates exhibited a reduction in proliferative and hypertrophic chondrocytes underlying the longitudinal growth retardation. Neonatal Perk−/− deficient mice show a 75% reduction in liver IGF-I mRNA and serum IGF-I within the first week, whereas the expression of IGF-I mRNA in most other tissues is normal. Injections of IGF-I partially reversed the growth retardation of the Perk−/− mice, whereas GH had no effect. Transgenic rescue of PERK activity in the insulin- secreting β-cells of the Perk−/− mice reversed the juvenile but not the neonatal growth retardation. We provide evidence that circulating IGF-I is derived from neonatal liver but is independent of GH at this stage. We propose that PERK is required to regulate the expression of IGF-I in the liver during the neonatal period, when IGF-I expression is GH-independent, and that the lack of this regulation results in severe neonatal growth retardation.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Endocrine Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1210/en.2003-0236"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1210/en.2003-0236 ","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Copyright"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.biomedcentral.com/about/license","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2003 by The Endocrine Society"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00137227 ","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"LI, Yulin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IIDA, Kaori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"O’NEIL, Jeff"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ZHANG, Peichuan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LI, Sheng’ai "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FRANK, Ami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GABAI, Aryn "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ZAMBITO, Frank "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LIANG, Shun-Hsin "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ROSEN, Clifford J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"CAVENER, Douglas R"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-03-11"}],"displaytype":"detail","filename":"3505.full.pdf","filesize":[{"value":"316.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","url":"https://ir.soken.ac.jp/record/3289/files/3505.full.pdf"},"version_id":"62a02e95-89ba-4e52-a572-6beedabd8662"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver"},{"subitem_title":"PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"21","path":["131","273"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-12-12"},"publish_date":"2012-12-12","publish_status":"0","recid":"3289","relation_version_is_last":true,"title":["PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver"],"weko_creator_id":"21","weko_shared_id":21},"updated":"2023-06-20T14:04:54.747956+00:00"}