{"created":"2023-06-20T13:23:00.335167+00:00","id":3761,"links":{},"metadata":{"_buckets":{"deposit":"416f1319-ba02-4553-9b23-80820993adbe"},"_deposit":{"created_by":21,"id":"3761","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3761"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003761","sets":["1:285","1:314"]},"author_link":["1563","778","357","1577","1600","1674"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-09-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageEnd":"11404","bibliographicPageStart":"11399","bibliographicVolumeNumber":"98","bibliographic_titles":[{"bibliographic_title":"Proceedings of the National Academy of Sciences of the United States of America  "},{"bibliographic_title":"Proceedings of the National Academy of Sciences of the United States of America  ","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"尚之, 高畑"}],"nameIdentifiers":[{},{},{}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inactivation of the CMP-N-acetylneuraminic acid hydroxylase gene has provided an example of human-specific genomic mutation that results in a widespread biochemical difference between human and nonhuman primates. We have found that, although a region containing a 92-bp exon and an AluSq element in the hydroxylase gene is intact in all nonhuman primates examined, the same region in the human genome is replaced by an AluY element that was disseminated at least one million years ago. We propose a mechanistic model for this Alu-mediated replacement event, which deleted the 92-bp exon and thus inactivated the human hydroxylase gene. It is suggested that Alu elements have played potentially important roles in genotypic and phenotypic evolution in the hominid lineage. ","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Academy of Sciences "}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"11562455","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1073/pnas.191268198"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1073/pnas.191268198 ","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2001, The National Academy of Sciences"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10916490","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HAYAKAWA, Toshiyuki "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SATTA, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GAGNEUX, Pascal "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAHATA, Naoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"VARKI, Ajit "}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene"},{"subitem_title":"Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"21","path":["285","314"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-08"},"publish_date":"2013-07-08","publish_status":"0","recid":"3761","relation_version_is_last":true,"title":["Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene"],"weko_creator_id":"21","weko_shared_id":21},"updated":"2023-06-20T14:30:34.839055+00:00"}