{"created":"2023-06-20T13:23:00.636584+00:00","id":3769,"links":{},"metadata":{"_buckets":{"deposit":"7855371e-d524-4efa-b106-2da289814572"},"_deposit":{"created_by":21,"id":"3769","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3769"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003769","sets":["1:314"]},"author_link":["1577","1613","778"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1983","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1052","bibliographicPageStart":" 1048","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Proceedings of the National Academy of Sciences of the United States of America  "},{"bibliographic_title":"Proceedings of the National Academy of Sciences of the United States of America  ","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"尚之, 高畑"}],"nameIdentifiers":[{"nameIdentifier":"1577","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030124217","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"30124217","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30124217"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To investigate the pattern of allelic distribution in enzyme polymorphism, with special reference to the relationship between the mean (H̄) and the variance (V(H)) of heterozygosity, we used the model of effectively neutral mutations involving multiple alleles in which selective disadvantage of mutant alleles follows a Γ distribution. A simulation method was developed that enables us to study efficiently the process of random drift in a multiallelic genetic system and that saves a great deal of computer time. It is an improved version of the pseudosampling-variable (PSV) method previously used to simulate random drift in a diallelic system. This method will be useful for simulating many models of population genetics that involve behavior of multiple alleles in a finite population. By using this method, it was shown that, as compared with the model of strictly neutral mutations, the present model gives the reduction of both H̄ and V(H) and an excess of rare variant alleles. The results were discussed in the light of recent observations on protein polymorphism with special reference to the functional constraint of proteins involved.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Academy of Sciences "}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"6573657","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1073/pnas.80.4.1048 "}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1073/pnas.80.4.1048 ","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© National Academy of Sciences "}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10916490","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KIMURA, Motoo "}],"nameIdentifiers":[{"nameIdentifier":"1613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAKAHATA, Naoyuki"}],"nameIdentifiers":[{"nameIdentifier":"778","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method"},{"subitem_title":"Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"21","path":["314"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-09"},"publish_date":"2013-07-09","publish_status":"0","recid":"3769","relation_version_is_last":true,"title":["Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method"],"weko_creator_id":"21","weko_shared_id":21},"updated":"2023-06-20T14:28:18.808173+00:00"}