{"created":"2023-06-20T13:23:10.936712+00:00","id":3958,"links":{},"metadata":{"_buckets":{"deposit":"0f46d09f-80ba-4264-8159-aee2d18b7599"},"_deposit":{"created_by":21,"id":"3958","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3958"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003958","sets":["1:293"]},"author_link":["3119","2066","368","2067"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"e12234","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"PLoS ONE "},{"bibliographic_title":"PLoS ONE ","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nMatricellular proteins, including periostin, modulate cell-matrix interactions and cell functions by acting outside of cells.\n\nMethods and Findings\nIn this study, however, we reported that periostin physically associates with the Notch1 precursor at its EGF repeats in the inside of cells. Moreover, by using the periodontal ligament of molar from periostin-deficient adult mice (Pn−/− molar PDL), which is a constitutively mechanically stressed tissue, we found that periostin maintained the site-1 cleaved 120-kDa transmembrane domain of Notch1 (N1™) level without regulating Notch1 mRNA expression. N1™ maintenance in vitro was also observed under such a stress condition as heat and H2O2 treatment in periostin overexpressed cells. Furthermore, we found that the expression of a downstream effector of Notch signaling, Bcl-xL was decreased in the Pn−/− molar PDL, and in the molar movement, cell death was enhanced in the pressure side of Pn−/− molar PDL.\n\nConclusion\nThese results suggest the possibility that periostin inhibits cell death through up-regulation of Bcl-xL expression by maintaining the Notch1 protein level under the stress condition, which is caused by its physical association with the Notch1 precursor.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1371/journal.pone.0012234"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0012234 ","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Copyright"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.plos.org/about/open-access/license/","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2010 Tanabe et al"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TANABE, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAYAMA, Issei "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIYAMA, Takashi "}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"et, al."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-09-18"}],"displaytype":"simple","filename":"fetchObject.pdf","filesize":[{"value":"633.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"fetchObject","url":"https://ir.soken.ac.jp/record/3958/files/fetchObject.pdf"},"version_id":"c3d1b9f4-5571-436b-b1e8-466d131787cd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Periostin Associates with Notch1 Precursor to Maintain Notch1 Expression under a Stress Condition in Mouse Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Periostin Associates with Notch1 Precursor to Maintain Notch1 Expression under a Stress Condition in Mouse Cells"},{"subitem_title":"Periostin Associates with Notch1 Precursor to Maintain Notch1 Expression under a Stress Condition in Mouse Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"21","path":["112","293"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-09-18"},"publish_date":"2013-09-18","publish_status":"0","recid":"3958","relation_version_is_last":true,"title":["Periostin Associates with Notch1 Precursor to Maintain Notch1 Expression under a Stress Condition in Mouse Cells"],"weko_creator_id":"21","weko_shared_id":21},"updated":"2023-06-20T14:16:17.940476+00:00"}