{"created":"2023-06-20T13:23:11.588543+00:00","id":3970,"links":{},"metadata":{"_buckets":{"deposit":"2432f22d-4127-483a-acf8-4d0021893e72"},"_deposit":{"created_by":21,"id":"3970","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3970"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003970","sets":["1:293"]},"author_link":["2099","368","3119"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"16","bibliographicPageEnd":"6307","bibliographicPageStart":"6299","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Molecular and Cellular Biology"},{"bibliographic_title":"Molecular and Cellular Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bloom's syndrome (BS) is an autosomal disorder characterized by predisposition to a wide variety of cancers. The gene product whose mutation leads to BS is the RecQ family helicase BLM, which forms a complex with DNA topoisomerase IIIα (Top3α). However, the physiological relevance of the interaction between BLM and Top3α within the cell remains unclear. We show here that Top3α depletion causes accumulation of cells in G2 phase, enlargement of nuclei, and chromosome gaps and breaks that occur at the same position in sister chromatids. The transition from metaphase to anaphase is also inhibited. All of these phenomena except cell lethality are suppressed by BLM gene disruption. Taken together with the biochemical properties of BLM and Top3α, these data indicate that BLM and Top3α execute the dissolution of sister chromatids. ","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1128/MCB.00702-06"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.1128/MCB.00702-06","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Copyright"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://journals.asm.org/site/misc/ASM_Author_Statement.xhtml","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 by American Society for Microbiology"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0270-7306","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SEKI, Masayuki "}],"nameIdentifiers":[{"nameIdentifier":"2099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TANABE, Hideyuki"}],"nameIdentifiers":[{"nameIdentifier":"368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et, al."}],"nameIdentifiers":[{"nameIdentifier":"3119","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-09-19"}],"displaytype":"simple","filename":"6299.full.pdf","filesize":[{"value":"690.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"6299.full","url":"https://ir.soken.ac.jp/record/3970/files/6299.full.pdf"},"version_id":"52ff5312-6ceb-4a4c-800c-d5e34f65329e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Bloom helicase and DNA topoisomerase III alpha are involved in the dissolution of sister chromatids","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bloom helicase and DNA topoisomerase III alpha are involved in the dissolution of sister chromatids"},{"subitem_title":"Bloom helicase and DNA topoisomerase III alpha are involved in the dissolution of sister chromatids","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"21","path":["112","293"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-09-19"},"publish_date":"2013-09-19","publish_status":"0","recid":"3970","relation_version_is_last":true,"title":["Bloom helicase and DNA topoisomerase III alpha are involved in the dissolution of sister chromatids"],"weko_creator_id":"21","weko_shared_id":21},"updated":"2023-06-20T14:16:05.733475+00:00"}