{"created":"2023-06-20T13:23:12.838281+00:00","id":3989,"links":{},"metadata":{"_buckets":{"deposit":"49e69cbb-e69b-47c4-9b71-5b290f367574"},"_deposit":{"created_by":21,"id":"3989","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"3989"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00003989","sets":["1:293"]},"author_link":["2148","368","3119","2147","2146","367","2149"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"818","bibliographicPageStart":"813","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Microbiology and Immunology "},{"bibliographic_title":"Microbiology and Immunology ","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田辺, 秀之"}],"nameIdentifiers":[{},{},{}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A subclonal cl.1-14 cell was established from a monocytic cell line U937 by a limiting dilution method. The anti-HIV-1 activity of some antiviral compounds was evaluated in HIV-1-infected cl.1-14 cells. The results demonstrated that although AZT was a potent inhibitor of HIV-1 replication in cl.1-14 cells, its 50% effective concentration (EC50) values was 80 times higher than that in HIV-1 infected MT-4 cells; the EC50 of AZT was 0.16 microM and 0.002 microM in cl.1-14 and MT-4 cells, respectively. In contrast, the anti-HIV-1 activity of ddA, ddI and ddC in cl.1-14 cells was comparable to that in MT-4 cells. The antiviral activity of nevirapine, dextran sulfate, curdlan sulfate and T22 did not differ significantly between the cl.1-14 and MT-4 cells. The antiviral activity of several compounds in the HIV-1-infected cl.1-14 cells was similar to that in the HIV-1JR-FL-infected human peripheral macrophages. Our results suggest that cl.1-14 cell cultures are very useful for estimating antiviral activity and more advantageous than the use of peripheral blood macrophages.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley-Blackwell"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"7869961","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pubmed/7869961","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Wiley-Blackwell"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-5600","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MIYANOKUROSAKI, N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKASHIMA , H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ICHIYAMA , K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INAZAWA, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANABE, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"et, al."}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937"},{"subitem_title":"A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"21","path":["293"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-09-25"},"publish_date":"2013-09-25","publish_status":"0","recid":"3989","relation_version_is_last":true,"title":["A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2023-06-20T15:23:24.549798+00:00"}