@article{oai:ir.soken.ac.jp:00004180, author = {蟻川, 謙太郎 and HALLETT, Mark A. and DELAAT, Joan L. and ARIKAWA, Kentaro and SCHLAMP, Cassandra L. and KONG, Fansheng and WILLIAMS, David S.}, journal = {Journal of Cell Science, Journal of Cell Science}, month = {Jul}, note = {application/pdf, Guanylate cyclases play an essential role in the recovery of vertebrate photoreceptor cells after light activation. Here, we have investigated how one such guanylate cyclase, RetGC-1, is distributed within light- and dark-adapted rod photoreceptor cells. Guanylate cyclase activity partitioned with the photoreceptor outer segment (OS) cytoskeleton in a light-sensitive manner. RetGC-1 was found to bind actin filaments in actin blot overlays, suggesting a mechanism for its association with the OS cytoskeleton. In retinal sections, this enzyme was immunodetected only in the OSs, where it appeared to be distributed throughout the disk membranes.}, pages = {1803--1812}, title = {Distribution of guanylate cyclase within photoreceptor outer segments}, volume = {109}, year = {1996} }