@article{oai:ir.soken.ac.jp:00004486,
 author = {印南, 秀樹 and TAKUNO, Shohei and INNAN, Hideki},
 issue = {2},
 journal = {Trends in Genetics, Trends in Genetics},
 month = {Feb},
 note = {Using Arabidopsis microRNA (miRNA)-mediated gene regulation system as a model, we investigated how complex systems evolve with special attention to selection to maintain the systems. We found that the copy number of miRNA genes within each system is a key factor to determine the complexity of the system, indicating a crucial role of gene duplication to increase the complexity. Furthermore, we show that the mode of selection to maintain the systems depend on their complexity levels.},
 pages = {56--59},
 title = {Evolution of complexity in miRNA-mediated gene regulation systems},
 volume = {24},
 year = {2008}
}