@article{oai:ir.soken.ac.jp:00004525, author = {渡辺, 正勝 and NEGISHI, Kazuo and WATANABE, Masakatsu and et, al.}, issue = {2}, journal = {環境変異原研究, Genes and environment : the official journal of the Japanese Environmental Mutagen Society}, month = {}, note = {The mechanisms of the toxic effects of UVA (320-400nm) irradiation remain unclear. The actions of monochromatic longer wavelength UVA, in particular, have been difficult to analyze because of a lack of a powerful light source; however, a UVA laser that can be used for biological studies was recently developed. In the current studies, we examined the effects of 364-nm irradiation on yeast cells using a potent UVA laser. We found that, when irradiated under aerobic conditions, yeast cells lacking Ogg1 glycosylase were more sensitive than those with Ogg1. The ability of the 364-nm light to kill the yeast cells was almost eliminated by purging with argon gas. The mutagenic effects of the UVA irradiation did not appear to be enhanced by a lack of Ogg1. These results indicate the killing of yeast cells by 364-nm UVA may be dependent on oxidation and may involve DNA lesions that can be repaired by Ogg1.}, pages = {74--76}, title = {Oxidative DNA damage induced by 364-nm UVA laser in yeast cells}, volume = {28}, year = {2006} }