{"created":"2023-06-20T13:24:04.465311+00:00","id":5425,"links":{},"metadata":{"_buckets":{"deposit":"b7a319e5-5e8f-4905-a8ff-64717e1f5cff"},"_deposit":{"created_by":24,"id":"5425","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"5425"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00005425","sets":["1:452"]},"author_link":["6306","6309","6871","6867","6307","6312","6874","6310","6313","6872","6873","6870","6869","6311","6868","6308"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"631","bibliographicPageStart":"623","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Immunogenetics"},{"bibliographic_title":"Immunogenetics","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"DISHAW, Larry J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OTA, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MUELLER, M Gail"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"CANNON, John P"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAIRE, Robert N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GWATNEY, Natasha R"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LITMAN, Ronda T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LITMAN, Gary W"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Innate immune gene repertoires are restricted primarily to germline variation. Adaptive immunity, by comparison, relies on somatic variation of germline-encoded genes to generate extraordinarily large numbers of non-heritable antigen recognition motifs. Invertebrates lack the key features of vertebrate adaptive immunity, but have evolved a variety of alternative mechanisms to successfully protect the integrity of \"self\"; in many cases, these appear to be taxon-specific innovations. In the protochordate Branchiostoma floridae (amphioxus), the variable region-containing chitin-binding proteins (VCBPs) constitute a multigene family (comprised of VCBPs 1-5), which possesses features that are consistent with innate immune-type function. A large number of VCBP alleles and haplotypes are shown to exhibit levels of polymorphism exceeding the elevated overall levels determined for the whole amphioxus genome (JGI). VCBP genes of the 2 and 5 types are distinguished further by a highly polymorphic segment (exon 2) in the N-terminal immunoglobulin domain, defined previously as a \"hypervariable region\" or a \"hotspot.\" Genomic deoxyribonucleic acid (DNA) and complementary DNA (cDNA) sequences from large numbers of animals representing different populations reveal further significant differences in sequence complexity within and across VCBP2/5 haplotypes that arise through overlapping mechanisms of genetic exchange, gene copy number variation as well as mutation and give rise to distinct allelic lineages. The collective observations suggest that mechanisms were in place at the time of divergence of the cephalochordates that could selectively hyperdiversify immune-type receptors within a multigene family.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Berlin Heidelberg"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"20652563","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1007/s00251-010-0464-x ＜SpringerLink Abstract＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1007/s00251-010-0464-x","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Article ＜PMC FREE Full Text : Author manuscript ; available in PMC 2013 July 10.＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707128/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"About Immunogenetics ＜Springer＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://link.springer.com/journal/251","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer-Verlag 2010"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID (NCID)","attribute_value_mlt":[{"subitem_source_identifier":"AA11624885","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_26":{"attribute_name":"Online ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1432-1211","subitem_source_identifier_type":"ISSN"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0093-7711","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_23":{"attribute_name":"著者注記","attribute_value_mlt":[{"subitem_text_value":"Tatsuya, Ota : Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor)"}]},"item_10001_text_24":{"attribute_name":"PMC番号","attribute_value_mlt":[{"subitem_text_value":"PMC3707128 "}]},"item_10001_text_25":{"attribute_name":"雑誌情報","attribute_value_mlt":[{"subitem_text_value":"Publication Start Year : 1974"},{"subitem_text_value":"Frequency : Monthly"}]},"item_10001_text_28":{"attribute_name":"論文注記","attribute_value_mlt":[{"subitem_text_value":"Published online : 22 July 2010"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"DISHAW, Larry J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OTA, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MUELLER, M Gail"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"CANNON, John P"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAIRE, Robert N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GWATNEY, Natasha R"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LITMAN, Ronda T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LITMAN, Gary W"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Variable region-containing chitin-binding protein","subitem_subject_scheme":"Other"},{"subitem_subject":"Evolution","subitem_subject_scheme":"Other"},{"subitem_subject":"Innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"Variable immunoglobulin","subitem_subject_scheme":"Other"},{"subitem_subject":"polymorphism","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus."},{"subitem_title":"The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"24","path":["111","452"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-23"},"publish_date":"2017-02-23","publish_status":"0","recid":"5425","relation_version_is_last":true,"title":["The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus."],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-20T14:16:18.769549+00:00"}