{"created":"2023-06-20T13:24:04.821179+00:00","id":5437,"links":{},"metadata":{"_buckets":{"deposit":"0334c996-74f8-46a0-9296-c9565b426069"},"_deposit":{"created_by":24,"id":"5437","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"5437"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00005437","sets":["1:452"]},"author_link":["6280","6276","6883","6879","6885","6278","6279","6281","6277","6275","6282","6223","6875","6878","6881","6880","6876","411","6882","6884","6877"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"78","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"BMC genetics"},{"bibliographic_title":"BMC genetics","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"DISHAW, Larry J"}],"nameIdentifiers":[{"nameIdentifier":"6875","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MUELLER, M Gail"}],"nameIdentifiers":[{"nameIdentifier":"6876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GWATNEY, Natasha"}],"nameIdentifiers":[{"nameIdentifier":"6877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"CANNON, John P"}],"nameIdentifiers":[{"nameIdentifier":"6878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAIRE, Robert N"}],"nameIdentifiers":[{"nameIdentifier":"6879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"LITMAN, Ronda T"}],"nameIdentifiers":[{"nameIdentifier":"6880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"AMEMIYA, Chris T"}],"nameIdentifiers":[{"nameIdentifier":"6881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OTA, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"6882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ROWEN, Lee"}],"nameIdentifiers":[{"nameIdentifier":"6883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GLUSMAN, Gustavo"}],"nameIdentifiers":[{"nameIdentifier":"6884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"LITMAN, Gary W"}],"nameIdentifiers":[{"nameIdentifier":"6885","nameIdentifierScheme":"WEKO"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The variable region-containing chitin-binding proteins (VCBPs) are found in protochordates and consist of two tandem immunoglobulin variable (V)-type domains and a chitin-binding domain. We previously have shown that these polymorphic genes, which primarily are expressed in the gut, exhibit characteristics of immune genes. In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire.","subitem_description_type":"Abstract"},{"subitem_description":"VCBP genes 1, 2, 4, and 5 are encoded in a single contiguous gene-rich chromosomal region and VCBP3 is encoded in a separate locus. The VCBPs exhibit extensive haplotype variation, including copy number variation (CNV), indel polymorphism and a markedly elevated variation in repeat type and density. In at least one haplotype, inverted repeats occur more frequently than elsewhere in the genome. Multi-animal cDNA screening, as well as transcriptional profilingusing a novel transfection system, suggests that haplotype-specific transcriptional variants may contribute to VCBP genetic diversity.","subitem_description_type":"Abstract"},{"subitem_description":"The availability of the Branchiostoma floridae genome (Joint Genome Institute, Brafl1), along with BAC and PAC screening and sequencing described here, reveal that the relatively limited number of VCBP genes present in the amphioxus genome exhibit exceptionally high haplotype variation. These VCBP haplotypes contribute a diverse pool of allelic variants, which includes gene copy number variation, pseudogenes, and other polymorphisms, while contributing secondary effects on gene transcription as well.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central / London"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"19046437","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1186/1471-2156-9-78 ＜Read free full text at BioMed Central＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1186/1471-2156-9-78","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Article ＜PMC FREE Full Txet＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632668/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Archive of BMC Gnenetics ＜PubMed Central＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/journals/31/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"About BMC Genetics ＜BioMed Central＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://bmcgenet.biomedcentral.com/about","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Dishaw et al; licensee BioMed Central Ltd. 2008"},{"subitem_rights":"This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID (NCID)","attribute_value_mlt":[{"subitem_source_identifier":"AA12034956","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_26":{"attribute_name":"Online ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1471-2156","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_23":{"attribute_name":"著者注記","attribute_value_mlt":[{"subitem_text_value":"Tatsuya, Ota : Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor)"}]},"item_10001_text_24":{"attribute_name":"PMC番号","attribute_value_mlt":[{"subitem_text_value":"PMC2632668"}]},"item_10001_text_25":{"attribute_name":"雑誌情報","attribute_value_mlt":[{"subitem_text_value":"Other Title(s) : BioMed Central genetics"},{"subitem_text_value":"Publication Start Year : 2000"},{"subitem_text_value":"Electronic only"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"DISHAW, Larry J"}],"nameIdentifiers":[{"nameIdentifier":"6275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MUELLER, M Gail"}],"nameIdentifiers":[{"nameIdentifier":"6276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GWATNEY, Natasha"}],"nameIdentifiers":[{"nameIdentifier":"6277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"CANNON, John P"}],"nameIdentifiers":[{"nameIdentifier":"6278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAIRE, Robert N"}],"nameIdentifiers":[{"nameIdentifier":"6279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"LITMAN, Ronda T"},{"creatorName":"LITMAN, Gary W"}],"nameIdentifiers":[{"nameIdentifier":"6223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"AMEMIYA, Chris T"}],"nameIdentifiers":[{"nameIdentifier":"6280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OTA, Tatsuya "}],"nameIdentifiers":[{"nameIdentifier":"411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ROWEN, Lee"}],"nameIdentifiers":[{"nameIdentifier":"6281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GLUSMAN, Gustavo"}],"nameIdentifiers":[{"nameIdentifier":"6282","nameIdentifierScheme":"WEKO"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Carrier Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chitin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chordata Nonvertebrate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chromosomes Artificial Bacterial","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene Dosage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Genetic Variation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Genome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Haplotypes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunoglobulin Variable Region","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Models Genetic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymorphism Genetic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcription Genetic ＜NLM MeSH Terms＞","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus."},{"subitem_title":"Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"24","path":["111","452"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-23"},"publish_date":"2017-02-23","publish_status":"0","recid":"5437","relation_version_is_last":true,"title":["Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus."],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-20T14:16:11.677191+00:00"}