{"created":"2023-06-20T13:24:05.056166+00:00","id":5443,"links":{},"metadata":{"_buckets":{"deposit":"893edc3f-f128-491a-88a3-52e6b04bc6e5"},"_deposit":{"created_by":24,"id":"5443","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"5443"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00005443","sets":["1:293"]},"author_link":["6333","6338","6334","6335","6331","6337","6332","6336"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"Article number : 20690 (2016)","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Scientific reports"},{"bibliographic_title":"Scientific reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Long noncoding RNAs (lncRNAs) have been implicated in many biological processes through epigenetic mechanisms. We previously reported that KCNQ1OT1, an imprinted antisense lncRNA in the human KCNQ1 locus on chromosome 11p15.5, is involved in cis-limited silencing within an imprinted KCNQ1 cluster. Furthermore, aberration of KCNQ1OT1 transcription was observed with a high frequency in colorectal cancers. However, the molecular mechanism of the transcriptional regulation and the functional role of KCNQ1OT1 in colorectal cancer remain unclear. Here, we show that the KCNQ1OT1 transcriptional level was significantly increased in human colorectal cancer cells in which β-catenin was excessively accumulated in the nucleus. Additionally, overexpression of β-catenin resulted in an increase in KCNQ1OT1 lncRNA-coated territory. On the other hand, knockdown of β-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1. We showed that β-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter. Our evidence indicates that β-catenin signaling may contribute to development of colorectal cancer by functioning as a novel lncRNA regulatory factor via direct targeting of KCNQ1OT1.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group / London"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"26868975","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/srep20690 ＜Springer Nature Open Access Article＞"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/srep20690","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"About Scientific reports ＜Springer Nature＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/srep/about","subitem_relation_type_select":"URI"}}]},"item_10001_rights_31":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Scientific Reports is an open access journal.  Articles in the journal are free to access, download, share, and re-use.   | http://www.nature.com/srep/about/open-access"}]},"item_10001_source_id_26":{"attribute_name":"Online ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_23":{"attribute_name":"著者注記","attribute_value_mlt":[{"subitem_text_value":"Hideyuki, Tanabe : Department of Evolutionary Studies of Biosystems Science, School of Advanced Sciences, SOKENDAI (The Graduate University for Advanced Studies)  *(Associate Professor) "}]},"item_10001_text_24":{"attribute_name":"PMC番号","attribute_value_mlt":[{"subitem_text_value":"PMC4751614"}]},"item_10001_text_25":{"attribute_name":"雑誌情報","attribute_value_mlt":[{"subitem_text_value":"Publication Start Year : 2011"},{"subitem_text_value":"Frequency : Continuously updated"},{"subitem_text_value":"Scientific Reports is an online, open access journal from the publishers of Nature. "}]},"item_10001_text_28":{"attribute_name":"論文注記","attribute_value_mlt":[{"subitem_text_value":"Published online : 12 February 2016"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SUNAMURA, Naohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHIRA, Takahito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATAOKA, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INAOKA, Daigo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANABE, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAYAMA, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OSHIMURA, Mitsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUGOH, Hiroyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-16"}],"displaytype":"detail","filename":"srep20690.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文 / Article","url":"https://ir.soken.ac.jp/record/5443/files/srep20690.pdf"},"version_id":"bda23133-3c1b-416e-bc3d-1e58bbbfbfea"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of functional KCNQ1OT1 lncRNA by β-catenin.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of functional KCNQ1OT1 lncRNA by β-catenin."},{"subitem_title":"Regulation of functional KCNQ1OT1 lncRNA by β-catenin.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"24","path":["293"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-16"},"publish_date":"2016-08-16","publish_status":"0","recid":"5443","relation_version_is_last":true,"title":["Regulation of functional KCNQ1OT1 lncRNA by β-catenin."],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-20T15:04:52.148345+00:00"}