{"created":"2023-06-20T13:24:10.686624+00:00","id":5562,"links":{},"metadata":{"_buckets":{"deposit":"21186823-4537-441f-ab43-8751e5c5d4d6"},"_deposit":{"created_by":24,"id":"5562","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"5562"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00005562","sets":["1:285"]},"author_link":["7038","7055","7045","7040","7039","7046","7051","7058","7060","7056","7037","7035","7053","7052","7041","7057","7043","7042","7047","7036","7054","7059","7049","7050","7044","7048"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"34349","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SHIGENO-NAKAZAWA, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KASAI, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KI, Sewon"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOSTYANOVSKAYA, Elina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"PAWLAK, Jana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAGISHI, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKIMOTO, Noriaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAIJI, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKADA, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WESTBROOK, Jody"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SATTA, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KIGAWA, Takanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMAMOTO, Akira"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CRK and CRKL adapter proteins play essential roles in development and cancer through their SRC homology 2 and 3 (SH2 and SH3) domains. To gain insight into the origin of their shared functions, we have investigated their evolutionary history. We propose a term, crk/crkl ancestral (crka), for orthologs in invertebrates before the divergence of CRK and CRKL in the vertebrate ancestor. We have isolated two orthologs expressed in the choanoflagellate Monosiga brevicollis, a unicellular relative to the metazoans. Consistent with its highly-conserved three-dimensional structure, the SH2 domain of M. brevicollis crka1 can bind to the mammalian CRK/CRKL SH2 binding consensus phospho-YxxP, and to the SRC substrate/focal adhesion protein BCAR1 (p130(CAS)) in the presence of activated SRC. These results demonstrate an ancient origin of the CRK/CRKL SH2-target recognition specificity. Although BCAR1 orthologs exist only in metazoans as identified by an N-terminal SH3 domain, YxxP motifs, and a C-terminal FAT-like domain, some pre-metazoan transmembrane proteins include several YxxP repeats in their cytosolic region, suggesting that they are remotely related to the BCAR1 substrate domain. Since the tyrosine kinase SRC also has a pre-metazoan origin, co-option of BCAR1-related sequences may have rewired the crka-dependent network to mediate adhesion signals in the metazoan ancestor.","subitem_description_type":"Abstract"}]},"item_10001_link_33":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_link_text":"27686861","subitem_link_url":"https://www.ncbi.nlm.nih.gov/pubmed/?term=27686861"}]},"item_10001_link_34":{"attribute_name":"PMC番号","attribute_value_mlt":[{"subitem_link_text":"PMC5043372","subitem_link_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group / London"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/srep34349 ＜Springer Nature Open Access Article＞"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/srep34349","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"About Scientific reports ＜Springer Nature＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/srep/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Article ＜PMC FREE Full text＞"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2016"},{"subitem_rights":"Scientific Reports is an open access journal. Articles in the journal are free to access, download, share, and re-use. "}]},"item_10001_source_id_26":{"attribute_name":"Online ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_23":{"attribute_name":"著者注記","attribute_value_mlt":[{"subitem_text_value":"Yoko Satta：Department of Evolutionary Studies of Biosystems, The Graduate University of Advanced Studies *(Professor)"}]},"item_10001_text_25":{"attribute_name":"雑誌情報","attribute_value_mlt":[{"subitem_text_value":"Publication Start Year : 2011"},{"subitem_text_value":"Frequency : Continuously updated"},{"subitem_text_value":"Scientific Reports is an online, open access journal from the publishers of Nature. "}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SHIGENO-NAKAZAWA, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KASAI, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KI, Sewon"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOSTYANOVSKAYA, Elina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"PAWLAK, Jana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAGISHI, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKIMOTO, Noriaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAIJI, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKADA, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WESTBROOK, Jody"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SATTA, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KIGAWA, Takanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMAMOTO, Akira"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-02"}],"displaytype":"detail","filename":"srep34349.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文 / Article","url":"https://ir.soken.ac.jp/record/5562/files/srep34349.pdf"},"version_id":"2ee8d434-0e3b-4e54-a73e-12008d0c3925"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A pre-metazoan origin of the CRK gene family and co-opted signaling network.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A pre-metazoan origin of the CRK gene family and co-opted signaling network."},{"subitem_title":"A pre-metazoan origin of the CRK gene family and co-opted signaling network.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"24","path":["285"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-08-02"},"publish_date":"2017-08-02","publish_status":"0","recid":"5562","relation_version_is_last":true,"title":["A pre-metazoan origin of the CRK gene family and co-opted signaling network."],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-20T15:03:57.260329+00:00"}