{"created":"2023-06-20T13:24:15.058377+00:00","id":5646,"links":{},"metadata":{"_buckets":{"deposit":"32990b88-82b6-4b68-b72c-e89e6e8a6ec6"},"_deposit":{"created_by":24,"id":"5646","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"5646"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00005646","sets":["33:34"]},"author_link":["8189","8188"],"item_2_creator_3":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATTA, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8189","nameIdentifierScheme":"WEKO"}]}]},"item_2_date_4":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-06-16","subitem_date_issued_type":"Created"}]},"item_2_description_13":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"22133007","subitem_description_type":"Other"}]},"item_2_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"研究期間","attribute_value_mlt":[{"subitem_description":"2010～2014","subitem_description_type":"Other"}]},"item_2_description_17":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）:\nヒトの主要組織適合性抗原遺伝子群(HLA)は病原菌に感染したことを感知するなど、免疫系で重要な役割を担う。このHLAは未知のウィルスや細菌に対応するため、ヒトのゲノムの中で最も多型的である。この多様性を形成し維持するメカニズムについて、以下の結果を得た。1) HLA6遺伝子座に働く自然選択の強度は高々3%程度である。2) HLA-DRB1遺伝子座対立遺伝子のペプチド結合領域でのアミノ酸進化速度が一定ではない、3) 対立遺伝子の中には他の霊長類で失われたことによりヒト特異的となった系統があることなどを明らかにした。その他に対立遺伝子間の遺伝的距離と結合するペプチドの種類数との関係を推定した。\n研究成果の概要（英文）:\nHuman major histocompatibility complex (human MHC, HLA) genes play an important role in the acquired immune system so as to recognize infection by bacteria and viruses and to activate the immune system in order to protect a body against the infection. Because HLA needs to recognize unpredictable pathogens, HLA genes are the most polymorphic loci among the human genome. We have examined mechanisms for the generation and the maintenance of HLA polymorphisms, and results were as follows: 1) Estimates of the strength of natural selection operating on the six HLA loci is at the most 3% 2) Amino acid substitution rate at the peptide binding region (PBR) among HLA-DRB1 allelic lineages is not uniform, 3) Human-specific DRB1 allelic lineages, which diverged 28 myr ago, resulted from the loss of the allelic lineages in other primates. Furthermore, the relationship between genetic distances between HLA-DRB1 alleles and the extent of repertories of its binding peptides were elucidated .","subitem_description_type":"Abstract"}]},"item_2_description_18":{"attribute_name":"科研費研究者番号","attribute_value_mlt":[{"subitem_description":"20222010 | https://kaken.nii.ac.jp/ja/search/?qm=20222010","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"科学研究費補助金研究成果報告書\n研究代表者：颯田 葉子［総合研究大学院大学先導科学研究科教授］ ","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN（科学研究費補助金データーベース） "}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-22133007/","subitem_relation_type_select":"URI"}}]},"item_2_text_19":{"attribute_name":"研究分野","attribute_value_mlt":[{"subitem_text_value":"分子進化学、集団遺伝学、進化生理学"}]},"item_2_text_20":{"attribute_name":"研究種目","attribute_value_mlt":[{"subitem_text_value":"新学術領域研究（研究領域提案型）"}]},"item_2_text_5":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_text_value":"2015"}]},"item_2_version_type_12":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"颯田, 葉子"}],"nameIdentifiers":[{"nameIdentifier":"8188","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-08"}],"displaytype":"simple","filename":"22133007seika_satta.pdf","filesize":[{"value":"333.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"研究成果報告書","url":"https://ir.soken.ac.jp/record/5646/files/22133007seika_satta.pdf"},"version_id":"080937fa-2510-4fe3-a9ed-d93562d4c97b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自然選択","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫機構","subitem_subject_scheme":"Other"},{"subitem_subject":"進化速度","subitem_subject_scheme":"Other"},{"subitem_subject":"ペプチド","subitem_subject_scheme":"Other"},{"subitem_subject":"病原菌","subitem_subject_scheme":"Other"},{"subitem_subject":"ペプチド結合領域","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA ペプチド結合能","subitem_subject_scheme":"Other"},{"subitem_subject":"平衡選択","subitem_subject_scheme":"Other"},{"subitem_subject":"アミノ酸置換速度","subitem_subject_scheme":"Other"},{"subitem_subject":"細菌・ウィルス","subitem_subject_scheme":"Other"},{"subitem_subject":"現生人類","subitem_subject_scheme":"Other"},{"subitem_subject":"脱アフリカ","subitem_subject_scheme":"Other"},{"subitem_subject":"超優性選択","subitem_subject_scheme":"Other"},{"subitem_subject":"DAAモデル","subitem_subject_scheme":"Other"},{"subitem_subject":"進化","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲノム","subitem_subject_scheme":"Other"},{"subitem_subject":"ハプロタイプ","subitem_subject_scheme":"Other"},{"subitem_subject":"組み換え","subitem_subject_scheme":"Other"},{"subitem_subject":"霊長類","subitem_subject_scheme":"Other"},{"subitem_subject":"多重遺伝子族","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子重複","subitem_subject_scheme":"Other"},{"subitem_subject":"エピトープ","subitem_subject_scheme":"Other"},{"subitem_subject":"対立遺伝子のターンオーバー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ＨＬＡと病原菌・ウイルスとの共進化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ＨＬＡと病原菌・ウイルスとの共進化"},{"subitem_title":"Coevolution between HLA and bacteria or viruses","subitem_title_language":"en"}]},"item_type_id":"2","owner":"24","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-08"},"publish_date":"2017-12-08","publish_status":"0","recid":"5646","relation_version_is_last":true,"title":["ＨＬＡと病原菌・ウイルスとの共進化"],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-20T14:56:08.188070+00:00"}