@techreport{oai:ir.soken.ac.jp:00005733,
 author = {SASAKI, Akira and 佐々木, 顕},
 month = {2017-08-23, 2018-05-22},
 note = {24115008, application/pdf, 2012～2016, 研究成果の概要(和文):ヒトの抗レトロウイルス蛋白質であるAPOBEC3G(A3G)と，それを拮抗阻害するHIV-1 Vifの共進化の数理モデル化を行い，Vif/A3G発現量の軍拡競争や共進化的振動の起こる条件を理論的に示した．また，宿主体内の複数部位で増殖するウイルスに対する最適な介入戦略をネットワーク動態の解析で明らかにした．
cell-to-cell感染を排除したHIV-1の感染実験と通常の培養実験の時系列データ解析により，cell-free感染とcell-to-cell感染の寄与率を定量化した．また，HIV-1制御因子A3Hの多型とVif多型の進化的なダイナミズムを，感染実験により明らかにした．
研究成果の概要(英文):Coevolution of anti-retroviral protein APOBEC3G (A3G) of humans and its inhibitor Vif of HIV-1 is mathematically modeled, and revealed the conditions with which coevolution ends up with equilibrium or indefinite escalation of their expression levels. Intra-host dynamics of viruses with multiple tropism is analyzed with the framework of network dynamics, and its RO-centrality analysis revealed the optimum intervention strategy that typically recommends extremely focused intervention to the most amplifying tissue.

Comparing the time series data of infection experiments that excluded cell-to-cell infection of HIV-1 and those with both cell-to-cell and cell-free infections, we quantified their relative contributions to the basic reproductive number of viruses. Infection experiments using polymorphic HIV restriction factor A3H reveals the roles of A3H restriction + type and this counteracting Vif type have played in the coevolutionary dynamism between and HIV-1., 90211937 | https://nrid.nii.ac.jp/nrid/1000090211937/, 科学研究費補助金研究成果報告書
研究代表者：佐々木顕[総合研究大学院大学先導科学研究科教授]},
 title = {ウイルスー宿主攻防の数理科学解析},
 year = {}
}