{"created":"2023-06-20T13:24:18.773202+00:00","id":5738,"links":{},"metadata":{"_buckets":{"deposit":"6ccdfb9f-e7f3-4ba1-ae95-e8260f56ff4d"},"_deposit":{"created_by":24,"id":"5738","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"5738"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00005738","sets":["33:34"]},"author_link":["10450","10451"],"item_2_creator_3":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATTA, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10451","nameIdentifierScheme":"WEKO"}]}]},"item_2_date_4":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-08-23","subitem_date_issued_type":"Created"}]},"item_2_description_13":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"15K14582","subitem_description_type":"Other"}]},"item_2_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"研究期間","attribute_value_mlt":[{"subitem_description":"2015～2016","subitem_description_type":"Other"}]},"item_2_description_17":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文):突然変異率がゲノム全体で一様ではないことは、酵母を除いて、動物・植物・細菌でも知られるようになってきた。最近、私達の研究グループでは、地衣化菌類のサルオガセ属の４遺伝子間に蓄積する同義塩基置換数の有意な差を発見した。本研究では、この蓄積する塩基置換数の不均一性の地衣化菌類でのゲノムレベルの一般性とその原因を明らかにすることを目的としている。ハコネサルオガセとコフクレサルオガセの101遺伝子座の塩基配列を用いて、この不均一性を確認するとともにその進化的な要因を明らかにすることを試みた。その結果、この不均一性は遺伝子座間の同義置換速度の不均一性に起因することが示唆された。 \n研究成果の概要(英文):The heterogeneity of the mutation rate within a genome has been known for animals, plants, and bacterias, but the heterogeneity in fungal genomes has not been fully understood. Recently, our group found the presence of a large variation in the per-site synonymous divergences among four genes between two lichens, Usnea hakanensis and U. bismolliuscula. In this study we aim to analyze the generality of this heterogeneity in their genomes and to examine their causes. Synonymous divergences of nucleotide sequences from 101 loci from two species revealed a large range of divergences from 0.046 to 0.337. Several statistical tests concluded that this range was caused by the heterogeneity of synonymous substitution rates among loci. The extent of rate heterogeneity was estimated to be 0.176+-0.413/site/unit time. In future, we will examine biological causes for this heterogeneity by investigating the relationship with codon usages, gene expression and methylation. 　 \n","subitem_description_type":"Abstract"}]},"item_2_description_18":{"attribute_name":"科研費研究者番号","attribute_value_mlt":[{"subitem_description":"20222010 | https://nrid.nii.ac.jp/ja/nrid/1000020222010/","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"科学研究費補助金研究成果報告書\n研究代表者:颯田葉子[ 総合研究大学院大学先導科学研究科教授]","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN(科学研究費補助金データーベース)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?kw=%E5%9C%B0%E8%A1%A3%E5%8C%96%E8%8F%8C%E9%A1%9E%E3%81%AE%E9%81%BA%E4%BC%9D%E5%AD%90%E9%80%B2%E5%8C%96%E9%80%9F%E5%BA%A6%E3%81%AE%E8%A7%A3%E6%9E%90","subitem_relation_type_select":"URI"}}]},"item_2_text_19":{"attribute_name":"研究分野","attribute_value_mlt":[{"subitem_text_value":"ゲノム進化学"}]},"item_2_text_20":{"attribute_name":"研究種目","attribute_value_mlt":[{"subitem_text_value":"挑戦的萌芽研究 "}]},"item_2_text_5":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_text_value":"2016"}]},"item_2_version_type_12":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"颯田, 葉子"}],"nameIdentifiers":[{"nameIdentifier":"10450","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-24"}],"displaytype":"simple","filename":"15K14582seika_satta.pdf","filesize":[{"value":"215.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"研究成果報告書","url":"https://ir.soken.ac.jp/record/5738/files/15K14582seika_satta.pdf"},"version_id":"b7252641-8be4-4072-b80f-95ca4f2e8a6a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"同義置換速度の不均一性","subitem_subject_scheme":"Other"},{"subitem_subject":"負の２項分布","subitem_subject_scheme":"Other"},{"subitem_subject":"祖先集団サイズ","subitem_subject_scheme":"Other"},{"subitem_subject":"オーソログとパラローグ","subitem_subject_scheme":"Other"},{"subitem_subject":"ガンマ分布","subitem_subject_scheme":"Other"},{"subitem_subject":"地衣化菌類","subitem_subject_scheme":"Other"},{"subitem_subject":"共生","subitem_subject_scheme":"Other"},{"subitem_subject":"同義置換速度","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲノム","subitem_subject_scheme":"Other"},{"subitem_subject":"分子進化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"地衣化菌類の遺伝子進化速度の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"地衣化菌類の遺伝子進化速度の解析"},{"subitem_title":"Analysis of evolutionary rate heterogeneity in lichenized fungi","subitem_title_language":"en"}]},"item_type_id":"2","owner":"24","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-24"},"publish_date":"2018-05-24","publish_status":"0","recid":"5738","relation_version_is_last":true,"title":["地衣化菌類の遺伝子進化速度の解析"],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-20T14:35:51.091735+00:00"}