{"created":"2023-06-20T13:24:18.839170+00:00","id":5739,"links":{},"metadata":{"_buckets":{"deposit":"4871320e-d5bb-42e9-ac01-11898f8426fe"},"_deposit":{"created_by":24,"id":"5739","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"5739"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00005739","sets":["33:34"]},"author_link":["10387","10386"],"item_2_creator_3":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OKADA, Yasunobu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_2_date_4":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-08-31","subitem_date_issued_type":"Created"}]},"item_2_description_13":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"15K15028","subitem_description_type":"Other"}]},"item_2_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"研究期間","attribute_value_mlt":[{"subitem_description":"2015～2016","subitem_description_type":"Other"}]},"item_2_description_17":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文):LRRC8Aがヒト細胞の容積感受性外向整流性アニオンチャネルVSORの重要構成分子であることが報告された。本研究では、①LRRC8Aは、マウス細胞のVSORにおいても本質的な役割を果たすこと、②本分子の関与は、酸感受性外向整流性アニオンチャネル（ASOR）、マキシアニオンチャネル（Maxi-Cl）、Ca2+賦活性アニオンチャネル（CaCC）やcAMP賦活性アニオンチャネル（CFTR）には見られず、VSOR特異的であること、しかし、③シスプラチン耐性がん細胞KCP-4のVSOR活性欠乏の原因には、LRRC8AやLRRC8B～Eは関与せず、未知の他分子の関与が不可欠であることを明らかにした。 \n研究成果の概要(英文):Recently, LRRC8A was reported to be the essential component of human volume-sensitive outwardly rectifying anion channel(VSOR). In this study, we have elucidated that LRRC8A is also essentially involved in mouse VSOR activity, whereas it is not involved in the activities of 4 other types of anion channels activated by acid, Ca2+, patch excision or cAMP, respectively. Also, we have shown that deficiency of VSOR activity in KCP-4 cells is not due to insufficient expression of LRRC8A/B/C/D/E, suggesting an involvement of some other molecule(s) in VSOR activity.  \n","subitem_description_type":"Abstract"}]},"item_2_description_18":{"attribute_name":"科研費研究者番号","attribute_value_mlt":[{"subitem_description":"10025661 | https://nrid.nii.ac.jp/ja/nrid/1000010025661/","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"科学研究費補助金研究成果報告書\n研究代表者:岡田泰伸[総合研究大学院大学学長]","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"KAKEN（科学研究費補助金データーベース）"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15028/","subitem_relation_type_select":"URI"}}]},"item_2_text_19":{"attribute_name":"研究分野","attribute_value_mlt":[{"subitem_text_value":"生理学一般"}]},"item_2_text_20":{"attribute_name":"研究種目","attribute_value_mlt":[{"subitem_text_value":"挑戦的萌芽研究 "}]},"item_2_text_5":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_text_value":"2016"}]},"item_2_version_type_12":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 泰伸"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-25"}],"displaytype":"simple","filename":"15K15028seika_okada.pdf","filesize":[{"value":"716.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"研究成果報告書","url":"https://ir.soken.ac.jp/record/5739/files/15K15028seika_okada.pdf"},"version_id":"98ce987b-33f3-4bbd-89ee-cf0c37aa50f0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アニオンチャネル","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞容積調節","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパク質－タンパク質相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞生理学","subitem_subject_scheme":"Other"},{"subitem_subject":"生理学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"容積感受性アニオンチャネルVSORと新規関連タンパク質LRRC8Aの相互作用機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"容積感受性アニオンチャネルVSORと新規関連タンパク質LRRC8Aの相互作用機構"},{"subitem_title":"Mechanisms of interaction between the volume-sensitive outwardly rectifying anion channel, VSOR and a novel membrane protein,LRRC8A.","subitem_title_language":"en"}]},"item_type_id":"2","owner":"24","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-25"},"publish_date":"2018-05-25","publish_status":"0","recid":"5739","relation_version_is_last":true,"title":["容積感受性アニオンチャネルVSORと新規関連タンパク質LRRC8Aの相互作用機構"],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-20T14:35:55.869092+00:00"}