{"created":"2023-06-20T13:20:49.497647+00:00","id":877,"links":{},"metadata":{"_buckets":{"deposit":"058de96d-d192-4e33-ba7c-11a5dc06d6dc"},"_deposit":{"created_by":1,"id":"877","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"877"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00000877","sets":["2:430:20"]},"author_link":["9802","9803","9801"],"item_1_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池尾, 一穂"}],"nameIdentifiers":[{"nameIdentifier":"9801","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_3":{"attribute_name":"フリガナ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イケオ, カズホ"}],"nameIdentifiers":[{"nameIdentifier":"9802","nameIdentifierScheme":"WEKO"}]}]},"item_1_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1992-03-16"}]},"item_1_degree_grantor_5":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"総合研究大学院大学"}]}]},"item_1_degree_name_6":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（理学）"}]},"item_1_description_12":{"attribute_name":"要旨","attribute_value_mlt":[{"subitem_description":" The serine protease is a typical example of the mosaic protein.
It is a suitable material for studying molecular evolution of genes
and proteins, because a gene (and thus a protein) is now considered
to be composed of domains of independent evolutionary origins. The
serine protease has a protease domain and a domain called the
kringle structure. The kringle structure is a typical motif that has a
pattern of disulfide bridges. The Kuniz-type protease inhibitor, a
protein inhibitor of the serine protease, has also a smaller size of the
kringle structure called the minikringle.
The purpose of this dissertation is to study the molecular
evolution of the serine proteases and the Kunitz-type protease
inhibitors, in order to elucidate the evolutionary process of mosaic
proteins. To accomplish this purpose, I studied the evolutionary
dynamics of these proteins from various aspects of molecular
evolution in the following chapters.
In Chapter 2, I explained the kringle structures of the serine
proteases and showed characteristic features of its molecular
evolution. In Chapter 3, I discussed the difference in evolutionary
pattern between the protease domains and kringle domains, in order
to exemplify domain shuffling occurring in the evolutionary course
of mosaic proteins. The molecular evolution of the Kunitz-type
protease inhibitors was discussed in Chapter 4, which explored the
evolutionary origin of the Kunitz-type domains inserted into various
proteins. In Chapter 5, I described the evolutionary relationships
between the kringle and kringle-like structures, for the purpose of
showing the possibility that these structures have undergone
indepcndent courses in molecular evolution of the mosaic proteins.
In conclusion, as mentioned in Chapter 6, I emphasized the
importance of domain shuffling in evolution of mosaic proteins.","subitem_description_type":"Other"}]},"item_1_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_1_description_7":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"総研大甲第16号","subitem_description_type":"Other"}]},"item_1_select_14":{"attribute_name":"所蔵","attribute_value_mlt":[{"subitem_select_item":"有"}]},"item_1_select_8":{"attribute_name":"研究科","attribute_value_mlt":[{"subitem_select_item":"生命科学研究科"}]},"item_1_select_9":{"attribute_name":"専攻","attribute_value_mlt":[{"subitem_select_item":"18 遺伝学専攻"}]},"item_1_text_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"1991"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IKEO, Kazuho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9803","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"simple","filename":"甲16_要旨.pdf","filesize":[{"value":"186.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"要旨・審査要旨 / Abstract, Screening Result","url":"https://ir.soken.ac.jp/record/877/files/甲16_要旨.pdf"},"version_id":"654d4d62-5188-43c9-a1a3-d3ee1e3e0785"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"simple","filename":"甲16_本文.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","url":"https://ir.soken.ac.jp/record/877/files/甲16_本文.pdf"},"version_id":"2581eb0c-908e-4916-813a-efd81458f6bf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化"},{"subitem_title":"Evolutionary Features of Serine Protease and its Inhibitor as Mosaic Proteins","subitem_title_language":"en"}]},"item_type_id":"1","owner":"1","path":["20"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-02-22"},"publish_date":"2010-02-22","publish_status":"0","recid":"877","relation_version_is_last":true,"title":["モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-06-20T14:43:41.250241+00:00"}