{"created":"2023-06-20T13:20:49.497647+00:00","id":877,"links":{},"metadata":{"_buckets":{"deposit":"058de96d-d192-4e33-ba7c-11a5dc06d6dc"},"_deposit":{"created_by":1,"id":"877","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"877"},"status":"published"},"_oai":{"id":"oai:ir.soken.ac.jp:00000877","sets":["2:430:20"]},"author_link":["9802","9803","9801"],"item_1_creator_2":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池尾, 一穂"}],"nameIdentifiers":[{}]}]},"item_1_creator_3":{"attribute_name":"フリガナ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イケオ, カズホ"}],"nameIdentifiers":[{}]}]},"item_1_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1992-03-16"}]},"item_1_degree_grantor_5":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"総合研究大学院大学"}]}]},"item_1_degree_name_6":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（理学）"}]},"item_1_description_12":{"attribute_name":"要旨","attribute_value_mlt":[{"subitem_description":"　　The serine protease is a typical example of the mosaic protein.<br /> It is a suitable material for studying molecular evolution of genes<br /> and proteins, because a gene (and thus a protein) is now considered<br /> to be composed of domains of independent evolutionary origins.　The<br /> serine protease has a protease domain and a domain called the<br />kringle structure. The kringle structure is a typical motif that has a<br />pattern of disulfide bridges. The Kuniz-type protease inhibitor, a<br />protein inhibitor of the serine protease, has also a smaller size of the<br />kringle structure called the minikringle.<br />　　The purpose of this dissertation is to study the molecular<br />evolution of the serine proteases and the Kunitz-type protease<br />inhibitors, in order to elucidate the evolutionary process of mosaic<br />proteins. 　　To accomplish this purpose, I studied the evolutionary<br />dynamics of these proteins from various aspects of molecular<br />evolution in the following chapters.<br />　　In Chapter 2, I explained the kringle structures of the serine<br /> proteases and showed characteristic features of its molecular<br /> evolution. In Chapter 3, I discussed the difference in evolutionary<br /> pattern between the protease domains and kringle domains, in order<br />to exemplify domain shuffling occurring in the evolutionary course<br />of mosaic proteins. The molecular evolution of the Kunitz-type<br />protease inhibitors was discussed in Chapter 4, which explored the<br /> evolutionary origin of the Kunitz-type domains inserted into various<br />proteins.　In Chapter 5, I described the evolutionary relationships<br /> between the kringle and kringle-like structures, for the purpose of<br />showing the possibility that these structures have undergone<br /> indepcndent courses　in molecular evolution of the mosaic proteins.<br />　　　In conclusion, as mentioned in Chapter 6, I emphasized the<br /> importance of domain shuffling in evolution of mosaic proteins.","subitem_description_type":"Other"}]},"item_1_description_18":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_1_description_7":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"総研大甲第16号","subitem_description_type":"Other"}]},"item_1_select_14":{"attribute_name":"所蔵","attribute_value_mlt":[{"subitem_select_item":"有"}]},"item_1_select_8":{"attribute_name":"研究科","attribute_value_mlt":[{"subitem_select_item":"生命科学研究科"}]},"item_1_select_9":{"attribute_name":"専攻","attribute_value_mlt":[{"subitem_select_item":"18 遺伝学専攻"}]},"item_1_text_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"1991"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IKEO, Kazuho","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"simple","filename":"甲16_要旨.pdf","filesize":[{"value":"186.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"要旨・審査要旨 / Abstract, Screening Result","url":"https://ir.soken.ac.jp/record/877/files/甲16_要旨.pdf"},"version_id":"654d4d62-5188-43c9-a1a3-d3ee1e3e0785"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"simple","filename":"甲16_本文.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","url":"https://ir.soken.ac.jp/record/877/files/甲16_本文.pdf"},"version_id":"2581eb0c-908e-4916-813a-efd81458f6bf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化"},{"subitem_title":"Evolutionary Features of Serine Protease and its Inhibitor as Mosaic Proteins","subitem_title_language":"en"}]},"item_type_id":"1","owner":"1","path":["20"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-02-22"},"publish_date":"2010-02-22","publish_status":"0","recid":"877","relation_version_is_last":true,"title":["モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-06-20T14:43:41.250241+00:00"}