2020-04-07T00:20:37Zhttps://ir.soken.ac.jp/?action=repository_oaipmhoai:ir.soken.ac.jp:000044332019-12-12T05:40:34Z00001:00275
The Extent of Linkage Disequilibrium and Haplotype Sharing Around a Polymorphic SiteThe Extent of Linkage Disequilibrium and Haplotype Sharing Around a Polymorphic Siteenghttp://id.nii.ac.jp/1013/00004232/Journal ArticleINNAN, HidekiNORDBORG, Magnus 秀樹, 印南Various expressions related to the length of a conserved haplotype around a polymorphism of known frequency are derived. We obtain exact expressions for the probability that no recombination has occurred in a sample or subsample. We obtain an approximation for the probability that no recombination that could give rise to a detectable recombination event (through the four-gamete test) has occurred. The probabilities can be used to obtain approximate distributions for the length of variously defined haplotypes around a polymorphic site. The implications of our results for data analysis, and in particular for detecting selection, are discussed. Genetics = Genetics 16514374442003-09-01The Genetics Society of America 0016-6731© 2003 by The Genetics Society of America