| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-08 |
| タイトル |
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タイトル |
Loss of urate oxidase activity in hominoids and its evolutionary implications |
| タイトル |
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タイトル |
Loss of urate oxidase activity in hominoids and its evolutionary implications |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
ODA, Masako
SATTA, Yoko
TAKENAKA, Osamu
TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We have determined and compared the promoter, coding, and intronic sequences of the urate oxidase (Uox) gene of various primate species. Although we confirm the previous observation that the inactivation of the gene in the clade of the human and the great apes results from a single CGA to TGA nonsense mutation in exon 2, we find that the inactivation in the gibbon lineage results from an independent nonsense mutation at a different CGA codon in exon 2 or from either one-base deletion in exon 3 or one-base insertion in exon 5, contrary to the previous claim that the cause is a 13-bp deletion in exon 2. We also find that compared with other organisms, the primate functional Uox gene is exceptional in terms of usage of CGA codons which are prone to TGA nonsense mutations. Nevertheless, we demonstrate rather strong selective constraint against nonsynonymous sites of the functional Uox gene and argue that this observation is consistent with the fact that the Uox gene is unique in the genome and evolutionarily conserved not only among animals but also among eukaryotes. Another finding that there are a few substitutions in the cis-acting element or CAAT-box (or both) of primate functional Uox genes may explain the lowered transcriptional activity. We suggest that although the inactivation of the hominoid Uox gene was caused by independent nonsense or frameshift mutations, the gene has taken a two-step deterioration process, first in the promoter and second in the coding region during primate evolution. It is also argued that the high concentration of uric acid in the blood of humans and nonhuman primates has developed molecular coevolution with the xanthine oxidoreductase in purine metabolism. However, it remains to be answered whether loss of Uox activity in hominoids is related to protection from oxidative damage and the prolonged life span. |
| 書誌情報 |
Molecular Biology and Evolution
en : Molecular Biology and Evolution
巻 19,
号 5,
p. 640-653,
発行日 2002
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| 出版者 |
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出版者 |
Oxford University Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
07374038 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
11961098 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/oxfordjournals.molbev.a004123 |
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関連名称 |
10.1093/oxfordjournals.molbev.a004123 |
| 権利 |
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権利情報 |
© 2013 Society for Molecular Biology and Evolution |
