ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 020 学位論文
  2. 生命科学研究科
  3. 18 遺伝学専攻

Evolutionary processes of gene splicing and gene silencing

https://ir.soken.ac.jp/records/1012
https://ir.soken.ac.jp/records/1012
44471bdc-82b3-491b-84a5-4f94cc883b64
名前 / ファイル ライセンス アクション
甲870_要旨.pdf 要旨・審査要旨 (214.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2010-02-22
タイトル
タイトル Evolutionary processes of gene splicing and gene silencing
タイトル
タイトル Evolutionary processes of gene splicing and gene silencing
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_46ec
資源タイプ thesis
著者名 金, 麗華

× 金, 麗華

金, 麗華

Search repository
フリガナ キン, レイカ

× キン, レイカ

キン, レイカ

Search repository
著者 JIN, Liuha

× JIN, Liuha

en JIN, Liuha

Search repository
学位授与機関
学位授与機関名 総合研究大学院大学
学位名
学位名 博士(理学)
学位記番号
内容記述タイプ Other
内容記述 総研大甲第870号
研究科
値 生命科学研究科
専攻
値 18 遺伝学専攻
学位授与年月日
学位授与年月日 2005-03-24
学位授与年度
値 2004
要旨
内容記述タイプ Other
内容記述 Living things increase their biological diversity by variable evolutionary mechanisms. Among these mechanisms, gene duplication and alternative splicing (A.S.) are the two major evolutionary routes that can bring the functional variation by increasing gene diversification. My research interest is to study about the evolutionary relationship between the two different phenomena by utilizing available all data resources. Results of this study showed that the percentage of A.S. locus in the singleton gene group was less than that in the duplicated gene group and the duplicate genes tended to have more A. S. isoforms than singleton genes. The results suggested that gene duplication would induce more alternative splicing events on the duplicate genes than on singletons possibly by reducing the functional constraint on the duplicates. process. <br /> The RNA-mediated gene silencing pathways are evolutionarily conserved. RNA interference is a widespread silencing mechanisms. Multicellular eukaryotes produce small RNA molecules (approximately 21-24 nuleotides) of two general types, miRNA and siRNA. They collectively function as sequence-specific guides to silence or regulate genes, transposons, and viruses and to modify chromatin and genome structure. This highlights a fundamental role of short RNAs in eukatyotic gene regulation and antiviral defense. Recently, 3 distinct small RNA directed silencing pathways are observed, such as the destruction of mRNA via siRNA, inhibition of mRNA translation via miRNA, and Epigenetic gene silencing via siRNA. It was also found that in these pathways the members of ribonclease III family play important role in diverse RNA maturation and decay. Here I investigated the evolution of Rnase III nucleases, Dicer as representative, to further figure out the evolutionary relations of 3 gene silencing pathways. And with the advantage of using genomic sequence as the subject, I also could detect some possible candidates for a particular functional domain or gene in un-annotated genomic region., and on the other hand, it can make more sure the judgement of Non-Existence of domain or gene in some species.
所蔵
値 有
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-20 16:09:20.080764
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3