| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2010-02-22 |
| タイトル |
|
|
タイトル |
Diversity of radial glial cells is formed along the dorso-ventral axis in the developing mouse spinal cord. |
| タイトル |
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|
タイトル |
Diversity of radial glial cells is formed along the dorso-ventral axis in the developing mouse spinal cord. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 著者名 |
小川, 泰弘
|
| フリガナ |
オガワ, ヤスヒロ
|
| 著者 |
OGAWA, Yasuhiro
|
| 学位授与機関 |
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学位授与機関名 |
総合研究大学院大学 |
| 学位名 |
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|
学位名 |
博士（理学） |
| 学位記番号 |
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内容記述タイプ |
Other |
|
内容記述 |
総研大甲第782号 |
| 研究科 |
|
|
値 |
生命科学研究科 |
| 専攻 |
|
|
値 |
20 生理科学専攻 |
| 学位授与年月日 |
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|
学位授与年月日 |
2004-03-24 |
| 学位授与年度 |
|
|
値 |
2003 |
| 要旨 |
|
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内容記述タイプ |
Other |
|
内容記述 |
The central nervous system (CNS) of the mammalian embryo is organized according to the expression of region-specific transcription factors along the anterior-posterior (A/P) and/or dorso-ventral (D/V) axis. For example, the dorsal ventricular zone (VZ) of the embryonic spinal cord expresses Pax3 and Pax7, the ventral VZ expresses Pax6, and the more ventral VZ expresses Nkx2.2. Properties of neuronal precursors located in the VZ are determined by the characteristic expression patterns of these transcription factors, leading to the generation of distinct classes of neurons. Recent studies demonstrated that radial glial cells produce neurons in addition to glia during CNS development. <br /> Thus, neuronal precursor diversity may reflect the diversity of radial glial cells. If the radial glial cells show diversity, astrocytes generated from them may also. To investigate this hypothesis, we analyzed the expression of radial glial cell markers and transcription factors in the mouse embryonic spinal cord. I show that radial glial cells vary in expression of the astrocyte-specific glutamate transporter(GLAST) and the brain-lipid-binding protein (BLBP) at embryonic day 12.5(E12.5). The region where GLAST is strongly expressed in the ventral radial glial cells is closely related to the Pax6-expressing domain, and the weakly expressed region corresponding to the Nkx2.2-expressing domain. Furthermore, dorsal radial fibers expressed ephrin-B1, where GLAST expression is negative. Thus, different types of radial glial cells exist according to the transcription factors at E12.5. Since GLAST is considered to be expressed when radial glial cells aregenerating astrocytes, there may also be diversity in glial precursor cells along the D/V axis in the mouse spinal cord. |
| 所蔵 |
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値 |
有 |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
要旨・審査要旨 / Abstract, Screening Result (186.8 kB)
