| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2010-02-22 |
| タイトル |
|
|
タイトル |
Analysis of local circuit of the superior colliculus using multielectrode stimulating/recording system |
| タイトル |
|
|
タイトル |
Analysis of local circuit of the superior colliculus using multielectrode stimulating/recording system |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 著者名 |
PHONGPHANPHANEE, Penphimon
|
| フリガナ |
フォンファンファニー, ペンフィモン
|
| 著者 |
PHONGPHANPHANEE, Penphimon
|
| 学位授与機関 |
|
|
|
学位授与機関名 |
総合研究大学院大学 |
| 学位名 |
|
|
学位名 |
博士（理学） |
| 学位記番号 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
総研大甲第1208号 |
| 研究科 |
|
|
値 |
生命科学研究科 |
| 専攻 |
|
|
値 |
20 生理科学専攻 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2008-09-30 |
| 学位授与年度 |
|
|
値 |
2008 |
| 要旨 |
|
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内容記述タイプ |
Other |
|
内容記述 |
The main goal of our study is to clarify the neuronal connection and signal<br /> processing within the local circuit of SC. We have introduced the new planar multi-<br /> electrode stimulating/recoding system that deals with the populations of neurons to<br />overcome the previous limitation of one-directional recording. This system records field<br /> potential simultaneously from 64 locations, 8x8 array with 150 μm inter-electrode space. <br /> Moreover, while recording the field potentials in slice, it is possible to perform whole-<br /> cell patch-clamp recording simultaneously. The interlaminar and intralaminar circuits of<br /> the SC are described in this paper. The spread of activity from the stimulation in the<br />superficial layers indicates the existence of visuomotor pathway. The signal arisen in the<br />sSC propagated in non-linear amplification, particularly in the dSC. The large area of<br />propagation covering almost entire dSC area shows that the motor vector occurring in the<br /> dSC preceding the orienting movement recruits a large population of dSC neurons, while<br />the center of mass is moving ventrally. Interestingly, it is found that the dSC stimulation<br />evoked the less spreading burst than that evoked by the sSC stimulation. Furthermore, the spontaneous bursts, proposed to share the basic mechanism with the presaccadic burst in the dSC, always originally occur in the sSC, and disappear when the Ih blocker was applied. <br /> In the lateral connection in the sSC, the horizontal slice comprising SGS and SO layer was tested. The SGS neurons were recorded by the whole-cell patch-clamp, while stimulations were initiated in the SO layer in the opposite side of slice. This method can preserve more the lateral circuit than the coronal or parasagittal slices. Using this new experimental model, the distant inhibitory connection in SGS layer is showed clearly. <br />The distant inhibition and nearby excitation are the basic concept of many computational model of attention. |
| 所蔵 |
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|
値 |
有 |
要旨・審査要旨 (367.6 kB)
