{"_buckets": {"deposit": "56acb078-7baf-4d3b-a894-59bb07adaaab"}, "_deposit": {"created_by": 1, "id": "1350", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "1350"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00001350", "sets": ["27"]}, "author_link": ["9669", "9671", "9670"], "item_1_biblio_info_21": {"attribute_name": "書誌情報（ソート用）", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-09-28", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_1_creator_2": {"attribute_name": "著者名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "吉田, 悟"}], "nameIdentifiers": [{"nameIdentifier": "9669", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_3": {"attribute_name": "フリガナ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ヨシダ, サトル"}], "nameIdentifiers": [{"nameIdentifier": "9670", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2001-09-28"}]}, "item_1_degree_grantor_5": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "総合研究大学院大学"}]}]}, "item_1_degree_name_6": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（理学）"}]}, "item_1_description_1": {"attribute_name": "ID", "attribute_value_mlt": [{"subitem_description": "2001514", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "要旨", "attribute_value_mlt": [{"subitem_description": "Size control is one of the fundamental subjects of biology. In nematode Caenorhabditis elegans, a TGF-β-like signaling pathway, Sma pathway, which is composed of the ligand DBL-1, serine/threonine protein kinase receptors SMA-6 and DAF-4, and cytoplasmic signaling components SMA- 2, SMA-3, and SMA-4, regulates body length of the worm. To further address the molecular mechanism of body length regulation in the nematode by the TGF-β-like signaling pathway, I examined the regional requirement for the type I receptor SMA-6. Using a SMA-6::GFP (green fluorescent protein) reporter gene, I found sma-6 to be highly expressed in the hypodermis in addition to pharynx and intestine, while the type II receptor DAF-4 is reported to be more broadly expressed. I then examined the ability of SMA-6 expressed in different regions of the C. elegans body to rescue the sma-6 phenotype (small) and found that hypodermal expression of SMA-6 is most important and sufficient for the growth and maintenance of body length. I also show that GATA sequences in the sma-6 promoter contribute to the hypodermal expression of sma-6. Finally, I show that the DBL-1 signaling in middle larval stage is significant to control body length.", "subitem_description_type": "Other"}]}, "item_1_description_18": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_1_description_7": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "総研大甲第556号", "subitem_description_type": "Other"}]}, "item_1_select_14": {"attribute_name": "所蔵", "attribute_value_mlt": [{"subitem_select_item": "有"}]}, "item_1_select_8": {"attribute_name": "研究科", "attribute_value_mlt": [{"subitem_select_item": "生命科学研究科"}]}, "item_1_select_9": {"attribute_name": "専攻", "attribute_value_mlt": [{"subitem_select_item": "X2 分子生物機構論専攻"}]}, "item_1_text_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "2001"}]}, "item_1_text_20": {"attribute_name": "業務メモ", "attribute_value_mlt": [{"subitem_text_value": "（2018年2月16日）本籍など個人情報の記載がある旧要旨・審査要旨を個人情報のない新しいものに差し替えた。承諾書等未確認。要確認該当項目修正のこと。"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "YOSHIDA, Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9671", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-02-17"}], "displaytype": "simple", "download_preview_message": "", "file_order": 0, "filename": "甲556_要旨.pdf", "filesize": [{"value": "212.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 212300.0, "url": {"label": "要旨・審査要旨 / Abstract, Screening Result ", "url": "https://ir.soken.ac.jp/record/1350/files/甲556_要旨.pdf"}, "version_id": "533df9cf-1fbd-4a63-8488-6ca21c9ffd97"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-02-17"}], "displaytype": "simple", "download_preview_message": "", "file_order": 1, "filename": "甲556_本文.pdf", "filesize": [{"value": "3.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 3400000.0, "url": {"label": "本文", "url": "https://ir.soken.ac.jp/record/1350/files/甲556_本文.pdf"}, "version_id": "c1e6c8e2-4b3b-46f5-93cd-1a178ac3cae1"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "A study on tissue specificity of DBL-1 signaling pathway that regulates body length in Caenorhabditis elegans", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A study on tissue specificity of DBL-1 signaling pathway that regulates body length in Caenorhabditis elegans"}, {"subitem_title": "A study on tissue specificity of DBL-1 signaling pathway that regulates body length in Caenorhabditis elegans", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "1", "path": ["27"], "permalink_uri": "https://ir.soken.ac.jp/records/1350", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-02-22"}, "publish_date": "2010-02-22", "publish_status": "0", "recid": "1350", "relation": {}, "relation_version_is_last": true, "title": ["A study on tissue specificity of DBL-1 signaling pathway that regulates body length in Caenorhabditis elegans"], "weko_shared_id": 1}