| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2010-02-22 |
| タイトル |
|
|
タイトル |
A study on tissue specificity of DBL-1 signaling pathway that regulates body length in Caenorhabditis elegans |
| タイトル |
|
|
タイトル |
A study on tissue specificity of DBL-1 signaling pathway that regulates body length in Caenorhabditis elegans |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 著者名 |
吉田, 悟
|
| フリガナ |
ヨシダ, サトル
|
| 著者 |
YOSHIDA, Satoru
|
| 学位授与機関 |
|
|
|
学位授与機関名 |
総合研究大学院大学 |
| 学位名 |
|
|
学位名 |
博士（理学） |
| 学位記番号 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
総研大甲第556号 |
| 研究科 |
|
|
値 |
生命科学研究科 |
| 専攻 |
|
|
値 |
X2 分子生物機構論専攻 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2001-09-28 |
| 学位授与年度 |
|
|
値 |
2001 |
| 要旨 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Size control is one of the fundamental subjects of biology. In nematode Caenorhabditis elegans, a TGF-β-like signaling pathway, Sma pathway, which is composed of the ligand DBL-1, serine/threonine protein kinase receptors SMA-6 and DAF-4, and cytoplasmic signaling components SMA- 2, SMA-3, and SMA-4, regulates body length of the worm. To further address the molecular mechanism of body length regulation in the nematode by the TGF-β-like signaling pathway, I examined the regional requirement for the type I receptor SMA-6. Using a SMA-6::GFP (green fluorescent protein) reporter gene, I found sma-6 to be highly expressed in the hypodermis in addition to pharynx and intestine, while the type II receptor DAF-4 is reported to be more broadly expressed. I then examined the ability of SMA-6 expressed in different regions of the C. elegans body to rescue the sma-6 phenotype (small) and found that hypodermal expression of SMA-6 is most important and sufficient for the growth and maintenance of body length. I also show that GATA sequences in the sma-6 promoter contribute to the hypodermal expression of sma-6. Finally, I show that the DBL-1 signaling in middle larval stage is significant to control body length. |
| 所蔵 |
|
|
値 |
有 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
要旨・審査要旨 / Abstract, Screening Result (212.3 kB)
