| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2010-02-22 |
| タイトル |
|
|
タイトル |
Analysis of the expression and function of ciliary neurotrophic factor(CNTF) in the developing nervous system |
| タイトル |
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|
タイトル |
Analysis of the expression and function of ciliary neurotrophic factor(CNTF) in the developing nervous system |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 著者名 |
畑, 克介
|
| フリガナ |
ハタ, カツスケ
|
| 著者 |
HATA, Katsusuke
|
| 学位授与機関 |
|
|
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学位授与機関名 |
総合研究大学院大学 |
| 学位名 |
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|
学位名 |
博士（理学） |
| 学位記番号 |
|
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内容記述タイプ |
Other |
|
内容記述 |
総研大甲第604号 |
| 研究科 |
|
|
値 |
生命科学研究科 |
| 専攻 |
|
|
値 |
X2 分子生物機構論専攻 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2002-03-22 |
| 学位授与年度 |
|
|
値 |
2001 |
| 要旨 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Ciliary neurotrophic factor（CNTF） attracts much attention, because it is a unique member of the interleukin‐6（IL‐6） family whose receptor subunit for ligand binding is exclusively expressed in the nervous system and muscle.CNTF supports survival and differentiation of various types of neurons and glial cells in vitro.The role of CNTF as a moderate neurotrophic factor on mature motor neurons has been demonstrated. However,its role in embryonic development remains unknown. I examined expression patterns of the IL‐6 family members and their receptors during the rodent embryonic development,and found a specific expression of CNTF in the pineal gland and eyes. In vitro assays showed that newborn rat pineal extract supports some specific neurotransmitter/neuropeptide gene expressions［including substance P（SP）and vasoactive intestinal polypeptide（VIP）;the gene expression of these peptides is known to be induced by CNTF in vitro] and survival of newborn rat sympathetic neurons. In contrast to the in vitro results，sympathetic innervation of the pineal gland in CNTF‐deficient mice showed no apparent difference from that of wild‐type mice.There were few preprotachykinin‐A（SP precursor protein）and VIP‐positive neurons among sympathetic neurons that innervate a pineal gland. These few VIP‐positive neurons in superior cervical ganglion were not different in number between adult CNTF knockout and wild‐type mice，implying that the CNTF signal in pineal glands may be usually unavailable for innervating sympathetic neurons. Finally, I discuss the role of CNTF on the photoreceptor development in pineal organ of different species. |
| 所蔵 |
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|
値 |
有 |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
要旨・審査要旨 / Abstract, Screening Result (192.6 kB)
