{"_buckets": {"deposit": "b652a738-25f5-4013-87c4-2c86b4805929"}, "_deposit": {"created_by": 21, "id": "1512", "owners": [21], "pid": {"revision_id": 0, "type": "depid", "value": "1512"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00001512", "sets": ["22"]}, "author_link": ["0", "0", "0"], "item_1_biblio_info_21": {"attribute_name": "書誌情報（ソート用）", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-09-30", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_1_creator_2": {"attribute_name": "著者名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "高浦, 加奈"}], "nameIdentifiers": [{"nameIdentifier": "0", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_3": {"attribute_name": "フリガナ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "タカウラ, カナ"}], "nameIdentifiers": [{"nameIdentifier": "0", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2009-09-30"}]}, "item_1_degree_grantor_5": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "総合研究大学院大学"}]}]}, "item_1_degree_name_6": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（理学）"}]}, "item_1_description_1": {"attribute_name": "ID", "attribute_value_mlt": [{"subitem_description": "2009532", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "要旨", "attribute_value_mlt": [{"subitem_description": "Blindsight\u0027 is a phenomenon in which patients with damage to their primary visual cortex (V1) exhibited residual visual function without visual awareness in their visual field affected by the damage. Patients deny any visual awareness in the affected visual field, but when they are forced, they can orient to visual stimuli in the affected visual field by pointing or saccades. The residual functions are attributed to the visual pathways bypassing the V1, including the extrageniculate pathway mediated by the superior colliculus (SC). Visual awareness seems to support our flexible use of visual information in daily life. Once we become aware of something in our vision, we can use them for thinking or imaging even after it disappears from the view. Such mental processes are supposed to depend on the ability to retain visual information available, which is often discussed with the term of ‘working memory’. Thus, the relationship between visual awareness and working memory has often become a topic in theoretical or experimental studies, and it is commonly accepted that they are tightly linked to each other. Thus, it is intriguing to examine whether visual information in the affected visual field after V1 damage is available for the tasks which require working memory. In this study, the authors investigated spatial working memory after V1 lesion by using the monkeys with unilateral V1 lesion. It was previously reported that monkeys with unilateral V1 lesion could make saccades or reach to visual stimuli in the affected visual field when they were forced to respond. However, when they were required to report whether the visual stimulus was presented or not, they failed to detect them. They behaved as if there was no stimulus. This phenomenon seems parallel to the dissociation between the visual awareness and the residual visual function observed in the patients. Thus, the monkeys with unilateral V1 lesion have been used as an animal model of blindsight.\u003cbr /\u003e　The authors examined the monkeys\u0027 capability for the memory-guided saccade task, which is commonly used as a task requiring spatial working memory. In this task, subjects have to retain the position of the briefly flashed visual stimulus (cue) in their memory. Two Japanese monkeys were used. Their left V1 was removed by suction. During the postoperative period, their recovery process and the area affected by the lesion were investigated with visually guided saccade task.\u003cbr /\u003eAfter their performance in this task reached the steady state, their performance in the memory-guided saccade task was examined.\u003cbr /\u003e　It is found that both monkeys could retain spatial memory of the cues presented in the affected visual field as long as 2 seconds. The success ratios were 91.7 % and 93.8 %, respectively in each monkey. This means that the visual information in the affected visual field is available for spatial working memory.\u003cbr /\u003e　To examine the neural mechanisms underlying the memory-guided behavior in the affected visual field, neuronal activity in the deeper layer of the SC was recorded. The deeper layer of the SC interacts with various regions of the cerebral cortex and is one of the key regions for control of saccades. Furthermore, because of the projection from the superficial layer of the SC which directly receives visual inputs from retina, its functional role is likely to become larger after V1 lesion. While the monkeys were performing the task in the affected visual field, activities of the 72 neurons in the ipsilesional SC (ipsi SC) were recorded. Responses to the visual stimuli presented in the affected visual field were observed in 58 neurons. Based on the activities during the visually-guided delayed saccade task, the neurons were classified into the 2 groups: visual and visuomotor neurons. In the ipsi SC, 12 visual and 46 visuomotor neurons were recorded. As a control, activities of 16 visual and 50 visuomotor neurons in the contralesional SC (contra SC) of the same monkeys were recorded while the monkeys were performing the task in the normal visual field. The magnitudes of the visual responses and those of the saccadic bursts were not significantly different between the contra and the ipsi SC.\u003cbr /\u003e　Clear difference in the neuronal activity between the contra and ipsi SC was found during the retention interval in the memory-guided saccade task. The majority of the neurons in the ipsi SC kept discharging throughout the temporal interval from the offset of the cue until the go-signal (delay period), in case the cue was presented inside the receptive field (RF). In correct trials, the persistent activities during the delay period discriminated whether the cue was presented inside the RF or outside the RF with high probabilities. It is noteworthy that the persistent activities during the delay period were observed not only in the visuomotor neurons but also in the visual neurons, which were supposed to play a minor role for saccade execution. In the contra SC, such persistent activities were observed only in a part of the neurons, and the magnitudes of them were significantly smaller than those in the ipsi SC. Analysis of error trials revealed that the persistent activities in the ipsi SC were correlated with the monkeys’ behavioral outcome. When the monkeys made error saccades toward the outside RF, the persistent activities decayed before the go-signals. In contrast, when the monkeys made error saccades toward the inside RF, the neurons discharged during the delay period. \u003cbr /\u003e　These results suggested that the persistent activities in the ipsi SC during the delay period might serve as a source of the spatial information required for performing memory-guided saccade task in the affected visual field. In normal monkeys, persistent activities in the memory-guided saccade task have been described in the prefrontal and posterior parietal cortex, supporting the key roles of these cerebral regions in spatial working memory. After V1 lesion, the SC might compensate for a part of the functional roles of these cerebral areas.\u003cbr /\u003e　Thus, the results challenge the currently prevailing idea about the relationship between visual awareness and working memory, and to the view of the working memory as inherent properties to the cerebral cortex.", "subitem_description_type": "Other"}]}, "item_1_description_7": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "総研大甲第1297号", "subitem_description_type": "Other"}]}, "item_1_select_14": {"attribute_name": "所蔵", "attribute_value_mlt": [{"subitem_select_item": "有"}]}, "item_1_select_16": {"attribute_name": "複写", "attribute_value_mlt": [{"subitem_select_item": "印刷物から複写可"}]}, "item_1_select_17": {"attribute_name": "公開状況", "attribute_value_mlt": [{"subitem_select_item": "要旨のみ公開"}]}, "item_1_select_8": {"attribute_name": "研究科", "attribute_value_mlt": [{"subitem_select_item": "生命科学研究科"}]}, "item_1_select_9": {"attribute_name": "専攻", "attribute_value_mlt": [{"subitem_select_item": "20 生理科学専攻"}]}, "item_1_text_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "2009"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "TAKAURA, Kana", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "0", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-02-17"}], "displaytype": "simple", "download_preview_message": "", "file_order": 0, "filename": "甲1297_要旨.pdf", "filesize": [{"value": "350.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 350600.0, "url": {"label": "要旨・審査要旨", "url": "https://ir.soken.ac.jp/record/1512/files/甲1297_要旨.pdf"}, "version_id": "adc48400-aa78-4efe-8492-2f9e1be89fb0"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Spatial working memory after lesion of the primary visual cortex", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Spatial working memory after lesion of the primary visual cortex"}, {"subitem_title": "Spatial working memory after lesion of the primary visual cortex", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "21", "path": ["22"], "permalink_uri": "https://ir.soken.ac.jp/records/1512", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-06-09"}, "publish_date": "2010-06-09", "publish_status": "0", "recid": "1512", "relation": {}, "relation_version_is_last": true, "title": ["Spatial working memory after lesion of the primary visual cortex"], "weko_shared_id": -1}