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  1. 010 学術雑誌論文
  2. 蟻川, 謙太郎 / ARIKAWA, Kentaro

Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration

https://ir.soken.ac.jp/records/3257
https://ir.soken.ac.jp/records/3257
350183af-2949-4472-8cab-b5fc427038ef
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-10
タイトル
タイトル Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration
タイトル
タイトル Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 ARIKAWA, Kentaro

× ARIKAWA, Kentaro

ARIKAWA, Kentaro

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MOLDAY, Laurie L

× MOLDAY, Laurie L

MOLDAY, Laurie L

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MOLDAY, Robert S

× MOLDAY, Robert S

MOLDAY, Robert S

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WILLIAMS, David S

× WILLIAMS, David S

WILLIAMS, David S

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著者別名 蟻川, 謙太郎

× 蟻川, 謙太郎

蟻川, 謙太郎

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抄録
内容記述タイプ Abstract
内容記述 The outer segments of vertebrate rod photoreceptor cells consist of an ordered stack of membrane disks, which, except for a few nascent disks at the base of the outer segment, is surrounded by a separate plasma membrane. Previous studies indicate that the protein, peripherin or peripherin/rds, is localized along the rim of mature disks of rod outer segments. A mutation in the gene for this protein has been reported to be responsible for retinal degeneration in the rds mouse. In the present study, we have shown by immunogold labeling of rat and ground squirrel retinas that peripherin/rds is present in the disk rims of cone outer segments as well as rod outer segments. Additionally, in the basal regions of rod and cone outer segments, where disk morphogenesis occurs, we have found that the distribution of peripherin/rds is restricted to a region that is adjacent to the cilium. Extension of its distribution from the cilium coincides with the formation of the disk rim. These results support the model of disk membrane morphogenesis that predicts rim formation to be a second stage of growth, after the first stage in which the ciliary plasma membrane evaginates to form open nascent disks. The results also indicate how the proteins of the outer segment plasma membrane and the disk membranes are sorted into their separate domains: different sets of proteins may be incorporated into membrane outgrowths during different growth stages of disk morphogenesis. Finally, the presence of peripherin/rds protein in both cone and rod outer segment disks, together with the phenotype of the rds mouse, which is characterized by the failure of both rod and cone outer segment formation, suggest that the same rds gene is expressed in both types of photoreceptor cells.
書誌情報 Journal of Cell Biology
en : Journal of Cell Biology

巻 116, 号 3, p. 659-667, 発行日 1992-02-01
出版者
出版者 Rockefeller University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 00219525
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 http://doi.org/10.1083/jcb.116.3.659
関連名称 10.1083/jcb.116.3.659
権利
権利情報 © 1992 Rockefeller University Press
関連サイト
識別子タイプ URI
関連識別子 http://www.rupress.org/site/subscriptions/terms.xhtml
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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