| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2012-12-12 |
| タイトル |
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タイトル |
Association of myosin with the connecting cilium of rod photoreceptors |
| タイトル |
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タイトル |
Association of myosin with the connecting cilium of rod photoreceptors |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
WILLIAMS, David S
HALLETT, Mark A.
ARIKAWA, Kentaro
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| 著者別名 |
蟻川, 謙太郎
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The cilium of a vertebrate photoreceptor cell connects the phototransductive outer segment of the cell to the inner segment. Previous studies have shown that, within the connecting cilium, there is a small cluster of actin filaments, which play a critical role in the formation of new disk membranes. Here, we have detected a polypeptide in rat rod outer segments that is recognized by myosin heavy chain antibodies and was found to possess other characteristics of conventional non-muscle myosin heavy chain: it comigrates in SDS-PAGE with non-muscle myosin heavy chain; it associates with the cytoskeleton of rod outer segments in an ATP-sensitive manner; and it binds to purified actin filaments in the absence of ATP. Myosin ATPase activity was also detected in isolated rod outer segments. Electron immunomicroscopy revealed that myosin is present in the small actin-containing domain within the connecting cilium at the site of disk membrane morphogenesis. These results pose the possibility that an actin-myosin contractile mechanism functions in the formation of new photoreceptor disk membranes. |
| 書誌情報 |
Journal of Cell Science
en : Journal of Cell Science
巻 103,
号 1,
p. 183-190,
発行日 1992-09-01
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| 出版者 |
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出版者 |
The Company of Biologists Ltd |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00219533 |
| 権利 |
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権利情報 |
© 1992 by Company of Biologists |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.biologists.com/copyright_permissions.html |
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関連名称 |
Copyright |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
183.full (5.0 MB)
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