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Mbs: Modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection
https://ir.soken.ac.jp/records/3301
https://ir.soken.ac.jp/records/3301933ec4ea-f582-42e9-affa-51f1c4745a48
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1471-2105-10-166 (239.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-12-18 | |||||
| タイトル | ||||||
| タイトル | Mbs: Modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection | |||||
| タイトル | ||||||
| タイトル | Mbs: Modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
TESHIMA, Kosuke M
× TESHIMA, Kosuke M× INNAN, Hideki |
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| 著者別名 |
印南, 秀樹
× 印南, 秀樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background The pattern of single nucleotide polymorphisms, or SNPs, contains a tremendous amount of information with respect to the mechanisms of the micro-evolutionary process of a species. The inference of the roles of these mechanisms, including natural selection, relies heavily on computer simulations. A coalescent simulation is extremely powerful in generating a large number of samples of DNA sequences from a population (species) when all mutations are neutral, and Hudson's ms software is frequently used for this purpose. However, it has been difficult to incorporate natural selection into the coalescent framework. Results We herein present a software application to generate samples of DNA sequences when there is a biallelic site targeted by selection. This software application, referred to as mbs, is developed by modifying Hudson's ms. The mbs software is so flexible that it can incorporate any arbitrary histories of population size changes and any mode of selection as long as selection is operating on a biallelic site. Conclusion mbs provides opportunities to investigate the effect of any mode of selection on the pattern of SNPs under various demography. |
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| 書誌情報 |
BMC Bioinformatics en : BMC Bioinformatics 巻 10, 発行日 2009-05-30 |
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| 出版者 | ||||||
| 出版者 | BioMed Central | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14712105 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19480708 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1186/1471-2105-10-166 | |||||
| 関連名称 | 10.1186/1471-2105-10-166 | |||||
| 権利 | ||||||
| 権利情報 | © 2009 Teshima and Innan; licensee BioMed Central Ltd | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.biomedcentral.com/about/license | |||||
| 関連名称 | Copyright | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
