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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki

Mbs: Modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection

https://ir.soken.ac.jp/records/3301
https://ir.soken.ac.jp/records/3301
933ec4ea-f582-42e9-affa-51f1c4745a48
名前 / ファイル ライセンス アクション
1471-2105-10-166.pdf 1471-2105-10-166 (239.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-18
タイトル
タイトル Mbs: Modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection
タイトル
タイトル Mbs: Modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 TESHIMA, Kosuke M

× TESHIMA, Kosuke M

TESHIMA, Kosuke M

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INNAN, Hideki

× INNAN, Hideki

INNAN, Hideki

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著者別名 印南, 秀樹

× 印南, 秀樹

印南, 秀樹

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抄録
内容記述タイプ Abstract
内容記述 Background
The pattern of single nucleotide polymorphisms, or SNPs, contains a tremendous amount of information with respect to the mechanisms of the micro-evolutionary process of a species. The inference of the roles of these mechanisms, including natural selection, relies heavily on computer simulations. A coalescent simulation is extremely powerful in generating a large number of samples of DNA sequences from a population (species) when all mutations are neutral, and Hudson's ms software is frequently used for this purpose.

However, it has been difficult to incorporate natural selection into the coalescent framework.

Results
We herein present a software application to generate samples of DNA sequences when there is a biallelic site targeted by selection. This software application, referred to as mbs, is developed by modifying Hudson's ms. The mbs software is so flexible that it can incorporate any arbitrary histories of population size changes and any mode of selection as long as selection is operating on a biallelic site.

Conclusion
mbs provides opportunities to investigate the effect of any mode of selection on the pattern of SNPs under various demography.
書誌情報 BMC Bioinformatics
en : BMC Bioinformatics

巻 10, 発行日 2009-05-30
出版者
出版者 BioMed Central
ISSN
収録物識別子タイプ ISSN
収録物識別子 14712105
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 19480708
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/1471-2105-10-166
関連名称 10.1186/1471-2105-10-166
権利
権利情報 © 2009 Teshima and Innan; licensee BioMed Central Ltd
関連サイト
識別子タイプ URI
関連識別子 http://www.biomedcentral.com/about/license
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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