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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki

Duplication and gene conversion in the Drosophila melanogaster genome

https://ir.soken.ac.jp/records/3303
https://ir.soken.ac.jp/records/3303
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-18
タイトル
タイトル Duplication and gene conversion in the Drosophila melanogaster genome
タイトル
タイトル Duplication and gene conversion in the Drosophila melanogaster genome
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 OSADA, Naoki

× OSADA, Naoki

OSADA, Naoki

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INNAN, Hideki

× INNAN, Hideki

INNAN, Hideki

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著者別名 印南, 秀樹

× 印南, 秀樹

印南, 秀樹

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抄録
内容記述タイプ Abstract
内容記述 Using the genomic sequences of Drosophila melanogaster subgroup, the pattern of gene duplications was investigated with special attention to interlocus gene conversion. Our fine-scale analysis with careful visual inspections enabled accurate identification of a number of duplicated blocks (genomic regions). The orthologous parts of those duplicated blocks were also identified in the D. simulans and D. sechellia genomes, by which we were able to clearly classify the duplicated blocks into post- and pre-speciation blocks. We found 31 post-speciation duplicated genes, from which the rate of gene duplication (from one copy to two copies) is estimated to be 1.0×10−9 per single-copy gene per year. The role of interlocus gene conversion was observed in several respects in our data: (1) synonymous divergence between a duplicated pair is overall very low. Consequently, the gene duplication rate would be seriously overestimated by counting duplicated genes with low divergence; (2) the sizes of young duplicated blocks are generally large. We postulate that the degeneration of gene conversion around the edges could explain the shrinkage of “identifiable” duplicated regions; and (3) elevated paralogous divergence is observed around the edges in many duplicated blocks, supporting our gene conversion–degeneration model. Our analysis demonstrated that gene conversion between duplicated regions is a common and genome-wide phenomenon in the Drosophila genomes, and that its role should be especially significant in the early stages of duplicated genes. Based on a population genetic prediction, we applied a new genome-scan method to test for signatures of selection for neofunctionalization and found a strong signature in a pair of transporter genes.
書誌情報 PLoS Genetics
en : PLoS Genetics

巻 4, 号 12, p. e1000305-e1000305, 発行日 2008-12-12
出版者
出版者 Public Library of Science
ISSN
収録物識別子タイプ ISSN
収録物識別子 15537390
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 19079581
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pgen.1000305
関連名称 10.1371/journal.pgen.1000305
権利
権利情報 © Osada, Innan
関連サイト
識別子タイプ URI
関連識別子 http://www.plos.org/about/open-access/license/
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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