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Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system
https://ir.soken.ac.jp/records/3322
https://ir.soken.ac.jp/records/3322ad65adcf-5a3d-48c9-91c4-898e255ed765
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1471-2148-11-79 (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2013-01-17 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
MONTANO, Adriana M
× MONTANO, Adriana M
× TSUJINO, Fumi
× TAKAHATA, Naoyuki
× SATTA, Yoko
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Background Innate immunity is the ancient defense system of multicellular organisms against microbial infection. The basis of this first line of defense resides in the recognition of unique motifs conserved in microorganisms, and absent in the host. Peptidoglycans, structural components of bacterial cell walls, are recognized by Peptidoglycan Recognition Proteins (PGRPs). PGRPs are present in both vertebrates and invertebrates. Although some evidence for similarities and differences in function and structure between them has been found, their evolutionary history and phylogenetic relationship have remained unclear. Such studies have been severely hampered by the great extent of sequence divergence among vertebrate and invertebrate PGRPs. Here we investigate the birth and death processes of PGRPs to elucidate their origin and diversity. Results We found that (i) four rounds of gene duplication and a single domain duplication have generated the major variety of present vertebrate PGRPs, while in invertebrates more than ten times the number of duplications are required to explain the repertoire of present PGRPs, and (ii) the death of genes in vertebrates appears to be almost null whereas in invertebrates it is frequent. Conclusion These results suggest that the emergence of new PGRP genes may have an impact on the availability of the repertoire and its function against pathogens. These striking differences in PGRP evolution of vertebrates and invertebrates should reflect the differences in the role of their innate immunity. Insights on the origin of PGRP genes will pave the way to understand the evolution of the interaction between host and pathogens and to lead to the development of new treatments for immune diseases that involve proteins related to the recognition of self and non-self. |
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| 書誌情報 |
BMC Evolutionary Biology en : BMC Evolutionary Biology 巻 11, 号 1, 発行日 2011-03 |
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| 出版者 | ||||||||||||||
| 出版者 | BioMed Central | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 14712148 | |||||||||||||
| PubMed番号 | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 21439073 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1186/1471-2148-11-79 | |||||||||||||
| 関連名称 | 10.1186/1471-2148-11-79 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | © BioMed Central | |||||||||||||
| 関連サイト | ||||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | http://www.biomedcentral.com/about/license | |||||||||||||
| 関連名称 | Copyright | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
