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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system

https://ir.soken.ac.jp/records/3322
https://ir.soken.ac.jp/records/3322
ad65adcf-5a3d-48c9-91c4-898e255ed765
名前 / ファイル ライセンス アクション
1471-2148-11-79.pdf 1471-2148-11-79 (1.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-01-17
タイトル
タイトル Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system
タイトル
言語 en
タイトル Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 MONTANO, Adriana M

× MONTANO, Adriana M

WEKO 816

MONTANO, Adriana M

Search repository
TSUJINO, Fumi

× TSUJINO, Fumi

WEKO 817

TSUJINO, Fumi

Search repository
TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 818

TAKAHATA, Naoyuki

Search repository
SATTA, Yoko

× SATTA, Yoko

WEKO 357

SATTA, Yoko

Search repository
著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background
Innate immunity is the ancient defense system of multicellular organisms against microbial infection. The basis of this first line of defense resides in the recognition of unique motifs conserved in microorganisms, and absent in the host. Peptidoglycans, structural components of bacterial cell walls, are recognized by Peptidoglycan Recognition Proteins (PGRPs). PGRPs are present in both vertebrates and invertebrates. Although some evidence for similarities and differences in function and structure between them has been found, their evolutionary history and phylogenetic relationship have remained unclear. Such studies have been severely hampered by the great extent of sequence divergence among vertebrate and invertebrate PGRPs. Here we investigate the birth and death processes of PGRPs to elucidate their origin and diversity.

Results
We found that (i) four rounds of gene duplication and a single domain duplication have generated the major variety of present vertebrate PGRPs, while in invertebrates more than ten times the number of duplications are required to explain the repertoire of present PGRPs, and (ii) the death of genes in vertebrates appears to be almost null whereas in invertebrates it is frequent.

Conclusion
These results suggest that the emergence of new PGRP genes may have an impact on the availability of the repertoire and its function against pathogens. These striking differences in PGRP evolution of vertebrates and invertebrates should reflect the differences in the role of their innate immunity. Insights on the origin of PGRP genes will pave the way to understand the evolution of the interaction between host and pathogens and to lead to the development of new treatments for immune diseases that involve proteins related to the recognition of self and non-self.
書誌情報 BMC Evolutionary Biology
en : BMC Evolutionary Biology

巻 11, 号 1, 発行日 2011-03
出版者
出版者 BioMed Central
ISSN
収録物識別子タイプ ISSN
収録物識別子 14712148
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 21439073
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/1471-2148-11-79
関連名称 10.1186/1471-2148-11-79
権利
権利情報 © BioMed Central
関連サイト
識別子タイプ URI
関連識別子 http://www.biomedcentral.com/about/license
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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