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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko

Effects of intra-locus recombination on HLA polymorphism

https://ir.soken.ac.jp/records/3323
https://ir.soken.ac.jp/records/3323
a15c7f4c-22f2-487a-a3fd-ffd6cd3c65fb
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-01-17
タイトル
タイトル Effects of intra-locus recombination on HLA polymorphism
タイトル
タイトル Effects of intra-locus recombination on HLA polymorphism
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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著者別名 颯田, 葉子

× 颯田, 葉子

颯田, 葉子

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抄録
内容記述タイプ Abstract
内容記述 The observed number of alleles (na) at some human major histocompatibility complex (HLA)loci is more than twice as large as the pairwise mean number (k̄B) of nonsynonymous nucleotide substitutions in the peptide-binding region (PBR), although the k̄B is about the same as that predicted by a model of balancing selection. In order to assess the joint effect of intra-locus recombination and balancing selection on the HLA polymorphism, large scale computer simulation is conducted. It reveals that (1) both rate and location of break points of recombination are crucial factors to determine na, (2) intra-locus recombination tends to decrease k̄B, and (3) the rate of PBR nonsynonymous substitutions is insensitive to the recombination rate. Although a large number of alleles can be generated by intra-locus recombination, this fact alone is insufficient to account for the HLA polymorphism. It is argued that even patchwork patterns of PBR motifs, presumably owing to intra-locus recombination, must be maintained primarily by balancing selection.
書誌情報 Hereditas
en : Hereditas

巻 127, 号 1-2, p. 105-112, 発行日 1997-11
出版者
出版者 Wiley
ISSN
収録物識別子タイプ ISSN
収録物識別子 00180661
PubMed番号
識別子タイプ PMID
関連識別子 9420476
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1601-5223.1997.00105.x
関連名称 10.1111/j.1601-5223.1997.00105.x
権利
権利情報 © 1999-2014 John Wiley & Sons, Inc.
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