ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko

Evolutionary history of the cancer immunity antigen MAGE gene family

https://ir.soken.ac.jp/records/3325
https://ir.soken.ac.jp/records/3325
5e6b8624-d1b5-4c86-8415-d33ccc6bf8f6
名前 / ファイル ライセンス アクション
journal.pone.0020365.pdf journal.pone.0020365 (1.2 MB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-01-17
タイトル
タイトル Evolutionary history of the cancer immunity antigen MAGE gene family
タイトル
タイトル Evolutionary history of the cancer immunity antigen MAGE gene family
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 KATSURA, Yukako

× KATSURA, Yukako

KATSURA, Yukako

Search repository
SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

Search repository
著者別名 颯田, 葉子

× 颯田, 葉子

颯田, 葉子

Search repository
抄録
内容記述タイプ Abstract
内容記述 The evolutionary mode of a multi-gene family can change over time, depending on the functional differentiation and local genomic environment of family members. In this study, we demonstrate such a change in the melanoma antigen (MAGE) gene family on the mammalian X chromosome. The MAGE gene family is composed of ten subfamilies that can be categorized into two types. Type I genes are of relatively recent origin, and they encode epitopes for human leukocyte antigen (HLA) in cancer cells. Type II genes are relatively ancient and some of their products are known to be involved in apoptosis or cell proliferation. The evolutionary history of the MAGE gene family can be divided into four phases. In phase I, a single-copy state of an ancestral gene and the evolutionarily conserved mode had lasted until the emergence of eutherian mammals. In phase II, eight subfamily ancestors, with the exception for MAGE-C and MAGE-D subfamilies, were formed via retrotransposition independently. This would coincide with a transposition burst of LINE elements at the eutherian radiation. However, MAGE-C was generated by gene duplication of MAGE-A. Phase III is characterized by extensive gene duplication within each subfamily and in particular the formation of palindromes in the MAGE-A subfamily, which occurred in an ancestor of the Catarrhini. Phase IV is characterized by the decay of a palindrome in most Catarrhini, with the exception of humans. Although the palindrome is truncated by frequent deletions in apes and Old World monkeys, it is retained in humans. Here, we argue that this human-specific retention stems from negative selection acting on MAGE-A genes encoding epitopes of cancer cells, which preserves their ability to bind to highly divergent HLA molecules. These findings are interpreted with consideration of the biological factors shaping recent human MAGE-A genes.
書誌情報 PLoS ONE
en : PLoS ONE

巻 6, 号 6, 発行日 2011
出版者
出版者 Public Library of Science
ISSN
収録物識別子タイプ ISSN
収録物識別子 19326203
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0020365
関連名称 10.1371/journal.pone.0020365
権利
権利情報 © 2011 Katsura, Satta
関連サイト
識別子タイプ URI
関連識別子 http://www.plos.org/about/open-access/license/
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-20 14:33:17.791339
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3