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Evolutionary history of the cancer immunity antigen MAGE gene family
https://ir.soken.ac.jp/records/3325
https://ir.soken.ac.jp/records/33255e6b8624-d1b5-4c86-8415-d33ccc6bf8f6
| 名前 / ファイル | ライセンス | アクション |
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journal.pone.0020365 (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2013-01-17 | |||||||||
| タイトル | ||||||||||
| タイトル | Evolutionary history of the cancer immunity antigen MAGE gene family | |||||||||
| タイトル | ||||||||||
| タイトル | Evolutionary history of the cancer immunity antigen MAGE gene family | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
KATSURA, Yukako
× KATSURA, Yukako
× SATTA, Yoko
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| 著者別名 |
颯田, 葉子
× 颯田, 葉子
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The evolutionary mode of a multi-gene family can change over time, depending on the functional differentiation and local genomic environment of family members. In this study, we demonstrate such a change in the melanoma antigen (MAGE) gene family on the mammalian X chromosome. The MAGE gene family is composed of ten subfamilies that can be categorized into two types. Type I genes are of relatively recent origin, and they encode epitopes for human leukocyte antigen (HLA) in cancer cells. Type II genes are relatively ancient and some of their products are known to be involved in apoptosis or cell proliferation. The evolutionary history of the MAGE gene family can be divided into four phases. In phase I, a single-copy state of an ancestral gene and the evolutionarily conserved mode had lasted until the emergence of eutherian mammals. In phase II, eight subfamily ancestors, with the exception for MAGE-C and MAGE-D subfamilies, were formed via retrotransposition independently. This would coincide with a transposition burst of LINE elements at the eutherian radiation. However, MAGE-C was generated by gene duplication of MAGE-A. Phase III is characterized by extensive gene duplication within each subfamily and in particular the formation of palindromes in the MAGE-A subfamily, which occurred in an ancestor of the Catarrhini. Phase IV is characterized by the decay of a palindrome in most Catarrhini, with the exception of humans. Although the palindrome is truncated by frequent deletions in apes and Old World monkeys, it is retained in humans. Here, we argue that this human-specific retention stems from negative selection acting on MAGE-A genes encoding epitopes of cancer cells, which preserves their ability to bind to highly divergent HLA molecules. These findings are interpreted with consideration of the biological factors shaping recent human MAGE-A genes. | |||||||||
| 書誌情報 |
PLoS ONE en : PLoS ONE 巻 6, 号 6, 発行日 2011 |
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| 出版者 | ||||||||||
| 出版者 | Public Library of Science | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 19326203 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0020365 | |||||||||
| 関連名称 | 10.1371/journal.pone.0020365 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2011 Katsura, Satta | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.plos.org/about/open-access/license/ | |||||||||
| 関連名称 | Copyright | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
