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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

Inter- and intra-specific gene-density-correlated radial chromosome territory arrangements are conserved in Old World monkeys

https://ir.soken.ac.jp/records/3514
https://ir.soken.ac.jp/records/3514
43b89daa-442a-4f36-9efc-f3c530e1b3ef
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-04-25
タイトル
タイトル Inter- and intra-specific gene-density-correlated radial chromosome territory arrangements are conserved in Old World monkeys
タイトル
タイトル Inter- and intra-specific gene-density-correlated radial chromosome territory arrangements are conserved in Old World monkeys
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TANABE, Hideyuki

× TANABE, Hideyuki

TANABE, Hideyuki

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KüPPER, Katrin

× KüPPER, Katrin

KüPPER, Katrin

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ISHIDA, Takafumi

× ISHIDA, Takafumi

ISHIDA, Takafumi

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NEUSSER, Michaela

× NEUSSER, Michaela

NEUSSER, Michaela

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MIZUSAWA, Hiroshi

× MIZUSAWA, Hiroshi

MIZUSAWA, Hiroshi

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著者別名 田辺 , 秀之

× 田辺 , 秀之

田辺 , 秀之

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抄録
内容記述タイプ Abstract
内容記述 Recently it has been shown that the gene-density correlated radial distribution of human 18 and 19 homologous chromosome territories (CTs) is conserved in higher primates in spite of chromosomal rearrangements that occurred during evolution. However, these observations were limited to apes and New World monkey species. In order to provide further evidence for the evolutionary conservation of gene-density-correlated CT arrangements, we extended our previous study to Old World monkeys. They comprise the remaining species group to be analyzed in order to obtain a comprehensive overview of the nuclear topology of human 18 and 19 homologous CTs in higher primates. In the present study we investigated four lymphoblastoid cell lines from three species of Old World monkeys by three-dimensional fluorescence in situ hybridization (3D-FISH): two individuals of Japanese macaque (Macaca fuscata), crab-eating macaque (Macaca fascicularis), and an interspecies hybrid individual between African green monkey (Cercopithecus aethiops) and Patas monkey (Erythrocebus patas). Our data demonstrate that gene-poor human 18 homologous CTs are located preferentially close to the nuclear periphery, whereas gene-dense human 19 homologous CTs are oriented towards the nuclear center in all cell lines analyzed. The gene-density-correlated positioning of human 18 and 19 homologous CTs is evolutionarily conserved throughout all major higher primate lineages, despite chromosomal inversions, fusions, fissions or reciprocal translocations that occurred in the course of evolution in these species. This remarkable preservation of a gene-density-correlated chromatin arrangement gives further support for a functionally relevant higher-order chromatin architecture.
書誌情報 Cytogenetic and Genome Research
en : Cytogenetic and Genome Research

巻 108, 号 1-3, p. 255-261, 発行日 2005
出版者
出版者 Karger
ISSN
収録物識別子タイプ ISSN
収録物識別子 14248581
PubMed番号
識別子タイプ PMID
関連識別子 15545738
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1159/000080824
関連名称 10.1159/000080824
権利
権利情報 © Karger
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