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  1. 010 学術雑誌論文
  2. 五條堀, 淳 / GOJOBORI, Jun

Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting nondisordered structure

https://ir.soken.ac.jp/records/3526
https://ir.soken.ac.jp/records/3526
40aabb85-8c13-4024-883f-bf69b247e8d9
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-05-02
タイトル
タイトル Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting nondisordered structure
タイトル
タイトル Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting nondisordered structure
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 GOJOBORI, Jun

× GOJOBORI, Jun

GOJOBORI, Jun

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UEDA, Shintaroh

× UEDA, Shintaroh

UEDA, Shintaroh

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著者別名 五條堀, 淳

× 五條堀, 淳

五條堀, 淳

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抄録
内容記述タイプ Abstract
内容記述 Homopolymeric amino acid repeats are tandem repeats of single amino acids. About 650 genes are known to have repeats of this kind comprising seven residues or more in the human genome. According to the evolutionary conservativeness, we classified the repeats into three categories: those whose length is conserved among mammals (CM), those whose length differs among nonprimate mammals but is conserved among primates (CP), and those whose length differs among primates (VP). The frequency of each repeat, especially Ala, Leu, Pro, and Glu repeats, varies greatly in each category. The 3D structure of homopolymeric amino acid repeats is considered to be intrinsically disordered. As expected, a large proportion of the repeats had a disordered structure, and nearly half of the repeats were predicted as completely disordered. However, a number of the repeats predicted to have nondisordered structure: 13% and 25% of the repeats for categories CM and VP, respectively. Comparison of the substitution rates showed a higher Ka/Ks ratio for the genes with not disordered repeats than the genes with disordered repeats. These results indicate that amino acid substitution rates have been elevated in the genes with nondisordered repeats.
書誌情報 Molecular Biology and Evolution
en : Molecular Biology and Evolution

巻 28, 号 1, p. 543-550, 発行日 2011-01
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 07374038
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/molbev/msq225
関連名称 10.1093/molbev/msq225
権利
権利情報 © The Author 2010. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
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