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Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting nondisordered structure
https://ir.soken.ac.jp/records/3526
https://ir.soken.ac.jp/records/352640aabb85-8c13-4024-883f-bf69b247e8d9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-05-02 | |||||||||
| タイトル | ||||||||||
| タイトル | Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting nondisordered structure | |||||||||
| タイトル | ||||||||||
| タイトル | Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting nondisordered structure | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
GOJOBORI, Jun
× GOJOBORI, Jun
× UEDA, Shintaroh
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| 著者別名 |
五條堀, 淳
× 五條堀, 淳
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Homopolymeric amino acid repeats are tandem repeats of single amino acids. About 650 genes are known to have repeats of this kind comprising seven residues or more in the human genome. According to the evolutionary conservativeness, we classified the repeats into three categories: those whose length is conserved among mammals (CM), those whose length differs among nonprimate mammals but is conserved among primates (CP), and those whose length differs among primates (VP). The frequency of each repeat, especially Ala, Leu, Pro, and Glu repeats, varies greatly in each category. The 3D structure of homopolymeric amino acid repeats is considered to be intrinsically disordered. As expected, a large proportion of the repeats had a disordered structure, and nearly half of the repeats were predicted as completely disordered. However, a number of the repeats predicted to have nondisordered structure: 13% and 25% of the repeats for categories CM and VP, respectively. Comparison of the substitution rates showed a higher Ka/Ks ratio for the genes with not disordered repeats than the genes with disordered repeats. These results indicate that amino acid substitution rates have been elevated in the genes with nondisordered repeats. | |||||||||
| 書誌情報 |
Molecular Biology and Evolution en : Molecular Biology and Evolution 巻 28, 号 1, p. 543-550, 発行日 2011-01 |
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| 出版者 | ||||||||||
| 出版者 | Oxford University Press | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 07374038 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1093/molbev/msq225 | |||||||||
| 関連名称 | 10.1093/molbev/msq225 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © The Author 2010. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. | |||||||||
