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  1. 010 学術雑誌論文
  2. 五條堀, 淳 / GOJOBORI, Jun

Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution

https://ir.soken.ac.jp/records/3630
https://ir.soken.ac.jp/records/3630
30fb5794-9a58-42d4-a007-3c6654349298
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-06-25
タイトル
タイトル Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution
タイトル
タイトル Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 GOJOBORI, Jun

× GOJOBORI, Jun

GOJOBORI, Jun

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TANG, Hua

× TANG, Hua

TANG, Hua

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AKEY, Joshua M

× AKEY, Joshua M

AKEY, Joshua M

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WU, Chung-I

× WU, Chung-I

WU, Chung-I

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著者別名 五條堀, 淳

× 五條堀, 淳

五條堀, 淳

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抄録
内容記述タイプ Abstract
内容記述 The selective forces acting on amino acid substitutions may be different in the two phases of molecular evolution: polymorphism and fixation. Negative selection and genetic drift may dominate the first phase, whereas positive selection may become much more significant in the second phase. However, the conventional dichotomy of synonymous vs. nonsynonymous changes does not offer the resolution needed to study the dynamics of these two phases. Following previously published methods, we separated amino acid changes into 75 elementary types (1-bp substitution between their respective codons). The likelihood of each type of amino acid change becoming polymorphic (PI, which stands for “polymorphic index”), relative to synonymous changes, can then be calculated. Similarly, the likelihood of fixation (FI, for “fixation index”), conditional on common polymorphisms, is also calculated. Using Perlegen and HapMap data on human polymorphisms and the chimpanzee sequences as the outgroup, we compared the evolutionary dynamics of the 75 elementary changes in the two phases. We found a strong “L-shaped” negative correlation (P < 0.001) between FI and PI. Only those changes with low PIs show FI > 1, which is often a signature of adaptive evolution. These patterns suggest that negative and positive selection operate more effectively on the same set of amino acid changes and that ≈10–13% of amino acid substitutions between humans and chimpanzee may be adaptive.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 104, 号 10, p. 3907-3912, 発行日 2009-05
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 19362746
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.0605565104
関連名称 10.1016/j.tig.2009.03.008
権利
権利情報 © 2007 by The National Academy of Sciences of the USA
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