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  1. 010 学術雑誌論文
  2. 飯田, 香穂里 / IIDA, Kaori

A test of translational selection at 'silent' sites in the human genome: Base composition comparisons in alternatively spliced genes

https://ir.soken.ac.jp/records/3639
https://ir.soken.ac.jp/records/3639
42d2fff9-28ab-4e6a-8b04-bd26b8c7c246
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-06-26
タイトル
タイトル A test of translational selection at 'silent' sites in the human genome: Base composition comparisons in alternatively spliced genes
タイトル
タイトル A test of translational selection at 'silent' sites in the human genome: Base composition comparisons in alternatively spliced genes
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 IIDA, Kaori

× IIDA, Kaori

IIDA, Kaori

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AKASHI, Hiroshi

× AKASHI, Hiroshi

AKASHI, Hiroshi

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著者別名 飯田, 香穂里

× 飯田, 香穂里

飯田, 香穂里

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抄録
内容記述タイプ Abstract
内容記述 Natural selection appears to discriminate among synonymous codons to enhance translational efficiency in a wide range of prokaryotes and eukaryotes. Codon bias is strongly related to gene expression levels in these species. In addition, between-gene variation in silent DNA divergence is inversely correlated with codon bias. However, in mammals, between-gene comparisons are complicated by distinctive nucleotide-content bias (isochores) throughout the genome. In this study, we attempted to identify translational selection by analyzing the DNA sequences of alternatively spliced genes in humans and in Drosophila melanogaster. Among codons in an alternatively spliced gene, those in constitutively expressed exons are translated more often than those in alternatively spliced exons. Thus, translational selection should act more strongly to bias codon usage and reduce silent divergence in constitutive than in alternative exons. By controlling for regional forces affecting base-composition evolution, this within-gene comparison makes it possible to detect codon selection at synonymous sites in mammals. We found that GC-ending codons are more abundant in constitutive than alternatively spliced exons in both Drosophila and humans. Contrary to our expectation, however, silent DNA divergence between mammalian species is higher in constitutive than in alternative exons.
書誌情報 Gene
en : Gene

巻 261, 号 1, p. 93-105, 発行日 2000-12-30
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 03781119
PubMed番号
識別子タイプ PMID
関連識別子 11164041
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/S0378-1119(00)00482-0
関連名称 10.1016/S0378-1119(00)00482-0
権利
権利情報 © 2000 Elsevier Science B.V.
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