WEKO3
アイテム
A test of translational selection at 'silent' sites in the human genome: Base composition comparisons in alternatively spliced genes
https://ir.soken.ac.jp/records/3639
https://ir.soken.ac.jp/records/363942d2fff9-28ab-4e6a-8b04-bd26b8c7c246
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-06-26 | |||||||||
| タイトル | ||||||||||
| タイトル | A test of translational selection at 'silent' sites in the human genome: Base composition comparisons in alternatively spliced genes | |||||||||
| タイトル | ||||||||||
| タイトル | A test of translational selection at 'silent' sites in the human genome: Base composition comparisons in alternatively spliced genes | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
IIDA, Kaori
× IIDA, Kaori
× AKASHI, Hiroshi
|
|||||||||
| 著者別名 |
飯田, 香穂里
× 飯田, 香穂里
|
|||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Natural selection appears to discriminate among synonymous codons to enhance translational efficiency in a wide range of prokaryotes and eukaryotes. Codon bias is strongly related to gene expression levels in these species. In addition, between-gene variation in silent DNA divergence is inversely correlated with codon bias. However, in mammals, between-gene comparisons are complicated by distinctive nucleotide-content bias (isochores) throughout the genome. In this study, we attempted to identify translational selection by analyzing the DNA sequences of alternatively spliced genes in humans and in Drosophila melanogaster. Among codons in an alternatively spliced gene, those in constitutively expressed exons are translated more often than those in alternatively spliced exons. Thus, translational selection should act more strongly to bias codon usage and reduce silent divergence in constitutive than in alternative exons. By controlling for regional forces affecting base-composition evolution, this within-gene comparison makes it possible to detect codon selection at synonymous sites in mammals. We found that GC-ending codons are more abundant in constitutive than alternatively spliced exons in both Drosophila and humans. Contrary to our expectation, however, silent DNA divergence between mammalian species is higher in constitutive than in alternative exons. | |||||||||
| 書誌情報 |
Gene en : Gene 巻 261, 号 1, p. 93-105, 発行日 2000-12-30 |
|||||||||
| 出版者 | ||||||||||
| 出版者 | Elsevier | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 03781119 | |||||||||
| PubMed番号 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 11164041 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1016/S0378-1119(00)00482-0 | |||||||||
| 関連名称 | 10.1016/S0378-1119(00)00482-0 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2000 Elsevier Science B.V. | |||||||||
