| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-06-27 |
| タイトル |
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タイトル |
The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species |
| タイトル |
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タイトル |
The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
IWASE, Mineyo
SATTA, Yoko
HIRAI, Yuriko
HIRAI, Hirohisa
IMAI, Hirotami
TAKAHATA, Naoyuki
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| 著者別名 |
岩瀬, 峰代
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The mammalian amelogenin (AMEL) genes are found on both the X and Y chromosomes (gametologous). Comparison of the genomic AMEL sequences in five primates and three other mammals reveals that the 5′ portion of the gametologous AMEL loci began to differentiate in the common ancestor of extant mammals, whereas the 3′ portion differentiated independently within species of different mammals. The boundary is marked by a transposon insertion in intron 2 and is shared by all species examined. In addition, 540-kb DNA sequences from the short arm of the human X chromosome are aligned with their Y gametologous sequences. The pattern and extent of sequence differences in the 5′ portion of the AMEL loci extend to a proximal region that contains the ZFX locus, and those in the 3′ portion extend all the way down to the pseudoautosomal boundary (PAB)1. We concluded that the AMEL locus spans an ancient PAB, and that both the ancient and present PABs were determined by chance events during the evolution of mammals and primates. Sex chromosome differentiation likely took place in a region that contains the male-determining loci by suppressing homologous recombination. |
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America
巻 100,
号 9,
p. 5258-5263,
発行日 2003-04-29
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| 出版者 |
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出版者 |
National Academy of Sciences |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10916490 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
12672962 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1073/pnas.0635848100 |
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関連名称 |
10.1073/pnas.0635848100 |
| 権利 |
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権利情報 |
© 2003, The National Academy of Sciences |
