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  1. 010 学術雑誌論文
  2. 岩瀬, 峰代 / IWASE, Mineyo
  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species

https://ir.soken.ac.jp/records/3652
https://ir.soken.ac.jp/records/3652
3f466df9-8f3f-4a8e-9ee0-dd381053d969
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-06-27
タイトル
タイトル The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species
タイトル
タイトル The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 IWASE, Mineyo

× IWASE, Mineyo

IWASE, Mineyo

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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HIRAI, Yuriko

× HIRAI, Yuriko

HIRAI, Yuriko

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HIRAI, Hirohisa

× HIRAI, Hirohisa

HIRAI, Hirohisa

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IMAI, Hirotami

× IMAI, Hirotami

IMAI, Hirotami

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 岩瀬, 峰代

× 岩瀬, 峰代

岩瀬, 峰代

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抄録
内容記述タイプ Abstract
内容記述 The mammalian amelogenin (AMEL) genes are found on both the X and Y chromosomes (gametologous). Comparison of the genomic AMEL sequences in five primates and three other mammals reveals that the 5′ portion of the gametologous AMEL loci began to differentiate in the common ancestor of extant mammals, whereas the 3′ portion differentiated independently within species of different mammals. The boundary is marked by a transposon insertion in intron 2 and is shared by all species examined. In addition, 540-kb DNA sequences from the short arm of the human X chromosome are aligned with their Y gametologous sequences. The pattern and extent of sequence differences in the 5′ portion of the AMEL loci extend to a proximal region that contains the ZFX locus, and those in the 3′ portion extend all the way down to the pseudoautosomal boundary (PAB)1. We concluded that the AMEL locus spans an ancient PAB, and that both the ancient and present PABs were determined by chance events during the evolution of mammals and primates. Sex chromosome differentiation likely took place in a region that contains the male-determining loci by suppressing homologous recombination.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 100, 号 9, p. 5258-5263, 発行日 2003-04-29
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 12672962
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.0635848100
関連名称 10.1073/pnas.0635848100
権利
権利情報 © 2003, The National Academy of Sciences
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