WEKO3
アイテム
HLA-DRB intron 1 sequences: Implications for the evolution of HLA-DRB genes and haplotypes
https://ir.soken.ac.jp/records/3668
https://ir.soken.ac.jp/records/36684673b2ae-bcb0-48e7-8c93-aa3ba59de8c4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-06-27 | |||||||||||
| タイトル | ||||||||||||
| タイトル | HLA-DRB intron 1 sequences: Implications for the evolution of HLA-DRB genes and haplotypes | |||||||||||
| タイトル | ||||||||||||
| タイトル | HLA-DRB intron 1 sequences: Implications for the evolution of HLA-DRB genes and haplotypes | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 著者 |
SATTA, Yoko
× SATTA, Yoko
× MAYER, Werner E
× KLEIN, Jan
|
|||||||||||
| 著者別名 |
颯田, 葉子
× 颯田, 葉子
|
|||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Human DRB genes encode β chains of the major histocompatibility complex (MHC) class II molecules. Although nine DRB loci have been mapped to the short arm of chromosome 6, an individual chromosome contains only one to five loci and is classified into one of five major haplotypes. To elucidate the origin of human DRB loci and haplotypes, intron 1 sequences approximately 5000 bp in length were determined for three DRB1 alleles (DRB 1∗03, DRB 1∗04, and DRB 1∗15) and five DRB genes (DRB2, DRB3, DRB4, DRB5, and DRB7). The sequences were subjected to phylogenetic analyses together with previously determined intron 4 and 5 sequences. The sequences provided two sources of information: Nucleotide substitutions that could be used to construct phylogenetic trees and to estimate divergence times and a set of insertions (mostly Alu elements) that reveal the order of splitting of duplicated genes. The combined data indicate that the ancestor of the human DRB genes was HLA-DRB 1∗04-like and that the DRB2, DRB7, DRB5, and DRB3 genes arose from this ancestor by four rounds of duplication 58, 56, 53, and 36 million years (MY) ago, respectively. The DRB4 gene may have arisen 46 MY ago by a deletion from the DRB 1 and DRB2 genes and the DRB6 gene is probably an allele at the DRB2 locus. During the course of its evolution, the DRB 1∗04 gene acquired an intron 1 segment (including two Alu elements) from a gene that became the ancestor of DRB1∗03. The present-day HLA-DR haplotypes were derived from three principal ancestral haplotypes: DRB 1-DRB2, DRB1-DRB5, and DRB1-DRB7. | |||||||||||
| 書誌情報 |
Human Immunology en : Human Immunology 巻 51, 号 1, p. 1-12, 発行日 1996-11 |
|||||||||||
| 出版者 | ||||||||||||
| 出版者 | Elsevier | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 01988859 | |||||||||||
| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1016/S0198-8859(96)00155-3 | |||||||||||
| 関連名称 | 10.1016/S0198-8859(96)00155-3 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | © American Society for Histocompatibility and Immunogenetics, 1996. | |||||||||||
