| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-06-27 |
| タイトル |
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タイトル |
Ancestral population sizes and species divergence times in the primate lineage on the basis of intron and BAC end sequences |
| タイトル |
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タイトル |
Ancestral population sizes and species divergence times in the primate lineage on the basis of intron and BAC end sequences |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
SATTA, Yoko
HICKERSON, Michael
WATANABE, Hidemi
O’hUigin, Colm
KLEIN, Jan
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| 著者別名 |
颯田, 葉子
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The effective sizes of ancestral populations and species divergence times of six primate species (humans, chimpanzees, gorillas, orangutans, and representatives of Old World monkeys and New World monkeys) are estimated by applying the two-species maximum likelihood (ML) method to intron sequences of 20 different loci. Examination of rate heterogeneity of nucleotide substitutions and intragenic recombination identifies five outrageous loci (ODC1, GHR, HBE, INS, and HBG). The estimated ancestral polymorphism ranges from 0.21 to 0.96% at major divergences in primate evolution. One exceptionally low polymorphism occurs when African and Asian apes diverged. However, taking into consideration the possible short generation times in primate ancestors, it is concluded that the ancestral population size in the primate lineage was no smaller than that of extant humans. Furthermore, under the assumption of 6 million years (myr) divergence between humans and chimpanzees, the divergence time of humans from gorillas, orangutans, Old World monkeys, and New World monkeys is estimated as 7.2, 18, 34, and 65 myr ago, respectively, which are generally older than traditional estimates. Beside the intron sequences, three other data sets of orthologous sequences are used between the human and the chimpanzee comparison. The ML application to these data sets including 58,156 random BAC end sequences (BES) shows that the nucleotide substitution rate is as low as 0.6–0.8 × 10−9 per site per year and the extent of ancestral polymorphism is 0.33–0.51%. With such a low substitution rate and short generation time, the relatively high extent of polymorphism suggests a fairly large effective population size in the ancestral lineage common to humans and chimpanzees. |
| 書誌情報 |
Journal of Molecular Evolution
en : Journal of Molecular Evolution
巻 59,
号 4,
p. 478-487,
発行日 2004-10
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| 出版者 |
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出版者 |
SpringerLink |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-2844 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
15638459 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
http://doi.org/10.1007/s00239-004-2639-2 |
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関連名称 |
10.1007/s00239-004-2639-2 |
| 権利 |
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権利情報 |
SpringerLink(The original publication is available at www.springerlink.com) |
